Wells R Glenn
H1233, Cardiac Imaging, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y4W7, Canada.
J Nucl Cardiol. 2016 Dec;23(6):1343-1347. doi: 10.1007/s12350-016-0498-z. Epub 2016 Apr 12.
In vivo molecular imaging is a challenging task and no single type of imaging system provides an ideal solution. Nuclear medicine techniques like SPECT and PET provide excellent sensitivity but have poor spatial resolution. Optical imaging has excellent sensitivity and spatial resolution, but light photons interact strongly with tissues and so only small animals and targets near the surface can be accurately visualized. CT and MRI have exquisite spatial resolution, but greatly reduced sensitivity. To overcome the limitations of individual modalities, molecular imaging systems often combine individual cameras together, for example, merging nuclear medicine cameras with CT or MRI to allow the visualization of molecular processes with both high sensitivity and high spatial resolution.
体内分子成像是一项具有挑战性的任务，没有单一类型的成像系统能提供理想的解决方案。像单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET）这样的核医学技术具有出色的灵敏度，但空间分辨率较差。光学成像具有出色的灵敏度和空间分辨率，但光子与组织强烈相互作用，因此只能准确可视化小动物和靠近表面的目标。计算机断层扫描（CT）和磁共振成像（MRI）具有极高的空间分辨率，但灵敏度大大降低。为了克服单个模态的局限性，分子成像系统通常将各个相机组合在一起，例如，将核医学相机与CT或MRI合并，以实现高灵敏度和高空间分辨率的分子过程可视化。
