Kimmel C A, Wellington D G, Farland W, Ross P, Manson J M, Chernoff N, Young J F, Selevan S G, Kaplan N, Chen C
Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC 20460.
Environ Health Perspect. 1989 Feb;79:209-15. doi: 10.1289/ehp.8979209.
A workshop was held to discuss potential advancements to improve the precision of risk estimates for developmental toxicity. This paper presents an overview of the discussions at the workshop, focusing on the risk assessment process and science policy considerations important in the use of quantitative models. Some of the pertinent biological considerations are reviewed, particularly those related to the repair capacity of the developing organism and how this affects the concept of a threshold for developmental toxicity effects, as well as the maternal and litter influences on developmental toxicity outcomes. Finally, the current status of use of quantitative approaches is described, possible short-term approaches are discussed, and future research needs in this area are outlined.
举办了一次研讨会，以讨论在提高发育毒性风险估计精度方面的潜在进展。本文概述了研讨会上的讨论内容，重点关注风险评估过程以及在使用定量模型时重要的科学政策考量。回顾了一些相关的生物学考量，特别是那些与发育中生物体的修复能力有关的考量，以及这如何影响发育毒性效应阈值的概念，还有母体和窝仔对发育毒性结果的影响。最后，描述了定量方法的使用现状，讨论了可能的短期方法，并概述了该领域未来的研究需求。
