Department of Biomedical Engineering, College of Life Science & Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
National Engineering Research Center for Nano-Medicine, Huazhong University of Science & Technology, Wuhan 430074, China.
Nanomedicine (Lond). 2016 May;11(9):1169-85. doi: 10.2217/nnm.16.9. Epub 2016 Apr 13.
Oral delivery via the gastrointestinal (GI) tract is the dominant route for drug administration. Orally delivered liposomal carriers can enhance drug solubility and protect the encapsulated theraputic agents from the extreme conditions found in the GI tract. Liposomes, with their fluid lipid bilayer membrane and their nanoscale size, can significantly improve oral absorption. Unfortunately, the clinical applications of conventional liposomes have been hindered due to their poor stability and availability under the harsh conditions typically presented in the GI tract. To overcome this problem, the surface modification of liposomes has been investigated. Although liposome surface modification has been extensively studied for oral drug delivery, no review exists so far that adequately covers this topic. The purpose of this paper is to summarize and critically analyze emerging trends in liposome surface modification for oral drug delivery.
口服经胃肠道（GI）给药是药物给药的主要途径。口服递药的脂质体载体可以提高药物的溶解度，并保护包裹的治疗剂免受胃肠道中发现的极端条件的影响。脂质体具有流体脂质双层膜和纳米级尺寸，可以显著改善口服吸收。不幸的是，由于其在胃肠道中通常存在的恶劣条件下的稳定性和可用性差，传统脂质体的临床应用受到了阻碍。为了解决这个问题，已经研究了脂质体的表面修饰。尽管已经对脂质体表面修饰进行了广泛的研究用于口服药物递送，但目前还没有一篇综述能够充分涵盖这个主题。本文的目的是总结和批判性分析用于口服药物递送的脂质体表面修饰的新兴趋势。
