Scott Jeffrey F, Thompson Cheryl L, Vyas Ritva, Honda Kord, Zender Chad, Rezaee Rod, Lavertu Pierre, Koon Henry, Cooper Kevin D, Gerstenblith Meg R
Department of Dermatology, Case Western Reserve University, and Case Comprehensive Cancer Center, University Hospitals Case Medical Center, Lakeside 3100 11100 Euclid Avenue, Cleveland, OH, 44106, USA.
Department of Family Medicine and Community Health, Case Western Reserve University, and Case Comprehensive Cancer Center, University Hospitals Case Medical Center, Cleveland, OH, USA.
J Cancer Res Clin Oncol. 2016 Jul;142(7):1529-37. doi: 10.1007/s00432-016-2156-x. Epub 2016 Apr 13.
Rarely, melanoma is discovered in the parotid gland without an identifiable primary site. It is not known how patients with parotid melanoma of unknown primary (PMUP) compare to those with a known primary (PMKP). As such, we describe the largest series of patients with PMUP to date and compare them to patients with PMKP.
We analyzed cases from three sources: (1) the University Hospitals Case Medical Center pathology database (n = 45), (2) the Surveillance, Epidemiology, and End Results 18 database (n = 33), and (3) a comprehensive literature search (n = 32).
PMUP patients were predominately male and presented at a mean age of 56 years. When compared to PMKP, PMUP cases were more likely to be diagnosed in the parotid parenchyma, present with stage IV disease, and develop distant metastases during follow-up in a shorter amount of time. However, there was no difference in overall survival between patients with PMUP and PMKP presenting with stage-matched disease.
Overall survival is similar for stage-matched patients with parotid melanoma presenting with an unknown and known primary site.
腮腺中发现的黑色素瘤很少没有可识别的原发部位。目前尚不清楚原发性不明的腮腺黑色素瘤（PMUP）患者与原发性已知的腮腺黑色素瘤（PMKP）患者相比情况如何。因此，我们描述了迄今为止最大系列的PMUP患者，并将他们与PMKP患者进行比较。
我们分析了来自三个来源的病例：（1）大学医院病例医疗中心病理数据库（n = 45），（2）监测、流行病学和最终结果18数据库（n = 33），以及（3）全面的文献检索（n = 32）。
PMUP患者以男性为主，平均发病年龄为56岁。与PMKP相比，PMUP病例更有可能在腮腺实质中被诊断出来，表现为IV期疾病，并且在随访期间在更短的时间内发生远处转移。然而，PMUP和PMKP且疾病分期匹配的患者之间的总生存期没有差异。
疾病分期匹配的原发性不明和已知的腮腺黑色素瘤患者的总生存期相似。
Zotero 插件