具有高细胞毒性和免疫器官靶向性的玉米醇溶蛋白共轭ZnO/Cd(OH)Cl分级纳米复合材料的绿色自组装
Green self-assembly of zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites with high cytotoxicity and immune organs targeting.
作者信息
Wang Hua-Jie, Cao Ying, Wang Cai-Feng, Cui Shi-Zhong, Mi Li-Wei, Miyazawa Teruo
机构信息
Center for Advanced Materials Research, Zhongyuan University of Technology, No. 1 Huaihe Road, Xinzheng Shuanghu Economic Development Zone, Zhengzhou 451191, P. R. China.
New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai 980-0845, Japan.
出版信息
Sci Rep. 2016 Apr 14;6:24387. doi: 10.1038/srep24387.
Inorganic nanomedicines in the fight against cancer have progressed rapidly during recent years, with the synergistic advantages of multifunctional nanosystems compared to single component. Herein, a drug-combination opinion was introduced into "nanomedicine" based on the understanding of Trojan horse-anti-tumor mechanism of inorganic nano-medicines. Moreover, we reported the green and facile synthesis route of mono-dispersed and rod-like zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites. We found that the nanocomposites exhibited high-efficiency killing ability to tumor cells through lipid peroxidation mediated-membrane disintegration route. The safety studies in BALB/c mice didn't detect injection anaphylaxis, hemolysis and cytotoxicity. More interestingly, the nano-composites could specially accumulate in liver and kidney, which will be helpful for targeting cure to these regional cancers.
近年来，用于抗癌的无机纳米药物发展迅速，与单一成分相比，多功能纳米系统具有协同优势。在此，基于对无机纳米药物“特洛伊木马”抗肿瘤机制的理解，将药物组合理念引入“纳米医学”。此外，我们报道了单分散棒状玉米醇溶蛋白共轭ZnO/Cd(OH)Cl分级纳米复合材料的绿色简便合成路线。我们发现，该纳米复合材料通过脂质过氧化介导的膜崩解途径对肿瘤细胞表现出高效杀伤能力。在BALB/c小鼠中的安全性研究未检测到注射过敏反应、溶血和细胞毒性。更有趣的是，该纳米复合材料可特异性地在肝脏和肾脏中蓄积，这将有助于针对这些部位的癌症进行靶向治疗。
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