Kovaleva L G, Reshetnikova M E, Kalinin N N, Petrova V I, Iakovleva O N
Gematol Transfuziol. 1989 Feb;34(2):9-12.
Patients with idiopathic thrombocytopenic purpura (ITP) tolerated well plasmapheresis. In no cases hemorrhage intensification was observed. An immediate clinical effect was recorded in all patients that correlated with the immunological parameters improvement in most of them. The platelet count significantly rose only in one patient immediately after the plasmapheresis course. The follow-up of the patients during 11-20 months has enabled revealing not only immediate clinical but also late hematological effect of plasmapheresis, that was manifest in a delayed rise of the platelet levels in most patients, and abolished resistance to glucocorticoids in one of them. It has been concluded that plasmapheresis produces immunocorrecting effect and could be used for the treatment of ITP patients.
特发性血小板减少性紫癜（ITP）患者对血浆置换耐受性良好。未观察到出血加剧的情况。所有患者均有即刻临床效果，且大多数患者的免疫参数有所改善。仅1例患者在血浆置换疗程后血小板计数立即显著升高。对患者进行11 - 20个月的随访发现，血浆置换不仅有即刻临床效果，还有延迟血液学效果，表现为大多数患者血小板水平延迟升高，其中1例患者对糖皮质激素的抵抗消失。得出结论：血浆置换具有免疫纠正作用，可用于治疗ITP患者。
