Diminished hypotensive response to isoproterenol in streptozotocin-diabetic rats.
作者信息
Jobidon C, Nadeau A, Tancrède G, Rousseau-Migneron S
机构信息
Unité de Recherche sur le Diabète, Le Centre Hospitalier de l'Université Laval, Sainte-Foy, Québec, Canada.
出版信息
Gen Pharmacol. 1989;20(1):39-45. doi: 10.1016/0306-3623(89)90058-x.
PMID:2707571
Abstract
- The cardiovascular reactivity of streptozotocin-diabetic rats has been evaluated with isoproterenol (ISO), a strong beta-adrenergic agonist able to produce, at large dose, myocardial infarction. 2. In the basal state, diabetic rats presented significantly lower heart rate (P less than 0.001), a decreased systolic (P less than 0.05) and an unaltered diastolic blood pressure compared to non-diabetics. 3. Following ISO stimulation, the chronotropic response was similar in both groups of rats, while the fall in systolic and diastolic pressure was markedly reduced compared to those of non-diabetic rats (P less than 0.001). 4. These results suggest that the vasodilation capacity of diabetic rats is diminished.
摘要
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