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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Stone T W, Paton D M

Department of Pharmacology and Clinical Pharmacology, School of Medicine, University of Auckland, New Zealand.

Gen Pharmacol. 1989;20(1):61-4. doi: 10.1016/0306-3623(89)90061-x.

Adenosine triphosphate (ATP), alpha beta-methylene ATP and the dinucleotides P1P4diadenosine tetraphosphate (AP4A) and P1P5-diadenosine pentaphosphate (AP5A) have been applied to preparations of the rat vas deferens in vitro in preliminary experiments designed to assess the feasibility of using such nucleotides to detect subtypes of the ATP receptor causing smooth muscle contractions. 2. Desensitisation to the dinucleotides induced a change in the profile of the response to ATP with the preferential loss of an early transient component. 3. Desensitisation to low concentrations of alpha beta-methylene ATP produced a greater loss of the later, slower component of contraction to ATP. 4. It is suggested that these components may therefore involve pharmacologically distinguishable nucleotide receptors.

在旨在评估使用此类核苷酸检测引起平滑肌收缩的ATP受体亚型可行性的初步实验中，三磷酸腺苷（ATP）、αβ-亚甲基ATP以及二核苷酸P1P4-二腺苷四磷酸（AP4A）和P1P5-二腺苷五磷酸（AP5A）已被应用于大鼠输精管的体外制备。2. 对二核苷酸脱敏导致对ATP反应的特征发生变化，早期瞬时成分优先丧失。3. 对低浓度αβ-亚甲基ATP脱敏导致对ATP收缩的后期较慢成分丧失更多。4. 因此表明这些成分可能涉及药理学上可区分的核苷酸受体。

Stone T W, Paton D M

Department of Pharmacology and Clinical Pharmacology, School of Medicine, University of Auckland, New Zealand.

Gen Pharmacol. 1989;20(1):61-4. doi: 10.1016/0306-3623(89)90061-x.

Adenosine triphosphate (ATP), alpha beta-methylene ATP and the dinucleotides P1P4diadenosine tetraphosphate (AP4A) and P1P5-diadenosine pentaphosphate (AP5A) have been applied to preparations of the rat vas deferens in vitro in preliminary experiments designed to assess the feasibility of using such nucleotides to detect subtypes of the ATP receptor causing smooth muscle contractions. 2. Desensitisation to the dinucleotides induced a change in the profile of the response to ATP with the preferential loss of an early transient component. 3. Desensitisation to low concentrations of alpha beta-methylene ATP produced a greater loss of the later, slower component of contraction to ATP. 4. It is suggested that these components may therefore involve pharmacologically distinguishable nucleotide receptors.

在旨在评估使用此类核苷酸检测引起平滑肌收缩的ATP受体亚型可行性的初步实验中，三磷酸腺苷（ATP）、αβ-亚甲基ATP以及二核苷酸P1P4-二腺苷四磷酸（AP4A）和P1P5-二腺苷五磷酸（AP5A）已被应用于大鼠输精管的体外制备。2. 对二核苷酸脱敏导致对ATP反应的特征发生变化，早期瞬时成分优先丧失。3. 对低浓度αβ-亚甲基ATP脱敏导致对ATP收缩的后期较慢成分丧失更多。4. 因此表明这些成分可能涉及药理学上可区分的核苷酸受体。