VEGF-B 通过脂肪血管修剪改善代谢健康。
VEGF-B Improves Metabolic Health through Vascular Pruning of Fat.
机构信息
Division of Regenerative Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre (VRC), 3000 Leuven, Belgium.
出版信息
Cell Metab. 2016 Apr 12;23(4):571-3. doi: 10.1016/j.cmet.2016.03.012.
PMID:27076071
Abstract
Unraveling the mechanism VEGF-receptors modulating metabolism has therapeutic implications. In this issue, Robciuc et al. (2016) demonstrate that VEGF-B, by displacing VEGF-A from VEGFR1 and activating VEGFR2, increases adipose tissue vascularity, improves insulin sensitivity, diminishes obesity, and alleviates metabolic syndrome.
摘要
阐明 VEGF 受体调节代谢的机制具有治疗意义。在本期杂志中，Robciuc 等人（2016 年）表明，VEGF-B 通过从 VEGFR1 上置换 VEGF-A 并激活 VEGFR2，增加脂肪组织的血管生成，改善胰岛素敏感性，减少肥胖，并缓解代谢综合征。
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