Schneider B M, Schlimok G, Riethmüller G, Witte J
Fortschr Med. 1989 Jan 20;107(2):59-63.
To date, the detection of individual micrometastases or disseminated tumor cells has not been possible with conventional diagnostic procedures. With the aid of new immunocytochemical investigation, however, histogenetically different cells can now be detected in the bone marrow. The monoclonal antibody, cytokeratin component 18, is most suitable for the detection of micrometastases from colorectal carcinoma. In 22 out of 82 patients with colorectal carcinoma, we were able to detect CK2-positive cells. The incidence of these "micrometastases" is represented as a function of primary tumor size, lymph node involvement, distant metastasis, and degree of malignancy of the tumor, age and sex of the patient, and tumor localization.
迄今为止，传统诊断方法尚无法检测出单个微转移灶或播散性肿瘤细胞。然而，借助新的免疫细胞化学研究，现在能够在骨髓中检测出组织发生学上不同的细胞。单克隆抗体细胞角蛋白成分18最适合检测结直肠癌的微转移灶。在82例结直肠癌患者中，我们在22例患者体内检测到了CK2阳性细胞。这些“微转移灶”的发生率与原发肿瘤大小、淋巴结受累情况、远处转移、肿瘤恶性程度、患者年龄和性别以及肿瘤定位有关。
