Wang Dan, Zhai Jun-Xia, Liu Dian-Wu
a Department of Epidemiology and Biostatistics, School of Public Health , Hebei Medical University , Shijiazhuang , China.
b Library , Hebei Medical University , Shijiazhuang , China.
Neurol Res. 2016 Feb;38(2):144-50. doi: 10.1080/01616412.2015.1126996. Epub 2016 Mar 16.
Studies examining whether glutathione S-transferase M1 (GSTM1) polymorphisms are associated with Parkinson's disease (PD) have reported inconsistent results. To clarify those inconsistencies, a meta-analysis was performed.
The electronic databases were searched for all publications regarding the association. Studies were included if they met the eligibility criteria. The strength of the association between GSTM1 polymorphisms and PD risk was measured by odds ratios (ORs) and 95% confidence intervals (CIs) in the recessive genetic model (null genotype vs. present genotype). Subgroup analyses by ethnicity and OR type were performed.
A total of 22 publications (23 studies) were included. There were 14, 7 and 2 studies with Caucasians, Asians and Latinos, respectively. OR types were 15 and 8 studies with crude and adjusted ORs, respectively. The combined results of the overall analysis showed that the GSTM1 null genotype was not significantly associated with PD risk (ORrandom-effects = 1.06, 95% CI = 0.95-1.19). In subgroup analyses by ethnicity, no significant associations were found in Caucasians, Asians or Latinos individually. Similarly, there were no associations in the subgroup analyses by OR type. There were no obvious publication biases in any of the comparisons.
The results of this meta-analysis suggest that the GSTM1 null genotype is not significantly associated with PD risk.
关于谷胱甘肽S-转移酶M1（GSTM1）基因多态性与帕金森病（PD）相关性的研究报告结果不一致。为了阐明这些不一致之处，进行了一项荟萃分析。
在电子数据库中检索所有关于该相关性的出版物。符合纳入标准的研究被纳入。在隐性遗传模型（纯合子基因型与杂合子基因型）中，通过比值比（OR）和95%置信区间（CI）来衡量GSTM1基因多态性与PD风险之间的关联强度。按种族和OR类型进行亚组分析。
共纳入22篇出版物（23项研究）。其中分别有14项、7项和2项研究涉及高加索人、亚洲人和拉丁裔。OR类型方面，分别有15项和8项研究采用了粗OR和校正后OR。总体分析的综合结果显示，GSTM1纯合子基因型与PD风险无显著相关性（随机效应OR = 1.06，95%CI = 0.95 - 1.19）。在按种族进行的亚组分析中，高加索人、亚洲人或拉丁裔个体中均未发现显著相关性。同样，按OR类型进行的亚组分析中也未发现相关性。在任何比较中均未发现明显的发表偏倚。
这项荟萃分析的结果表明，GSTM1纯合子基因型与PD风险无显著相关性。
