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使用密网支架血管内治疗颅内动脉瘤:巴塞罗那四个中心的经验

Endovascular treatment of intracraneal aneurysm with pipeline embolization device: experience in four centres in Barcelona.

作者信息

Tomasello Alejandro, Romero Nicolas, Aixut Sonia, Miquel Maria A, Macho Juan M, Castaño Carlos, Coscojuela Pilar, Lemus Miguel, Aja Lucia, San Roman Luis, Blasco Jordi, Rovira Alex

机构信息

a Hospital Universitari de Vall d'Hebron , Barcelona , Spain.

b Hospital Universitari de Bellvitge , Barcelona , Spain.

出版信息

Neurol Res. 2016 May;38(5):381-8. doi: 10.1080/01616412.2016.1155335. Epub 2016 Apr 7.

DOI:10.1080/01616412.2016.1155335
PMID:27078708
Abstract

UNLABELLED

Flow diverters represent a useful tool in the treatment of fusiform aneurysms and wide-neck saccular aneurysms which until the advent of this technology were problematic to treat. Pipeline™ Embolization Device (PED) has been described in several series showing high rates of occlusion and being relatively safe.

OBJECTIVE

Shows the experience in four different neurointerventional centres in Barcelona with the PED (Covidien) between February 2010 and October 2013.

METHODS

We reviewed retrospectively patients treated with PED in four neurointerventional centres in Barcelona between February 2010 and October 2013.

RESULTS

Forty-two patients (89.4%) with non-ruptured aneurysms and five (10.6%) post-SAH were treated, with a mean age of 51 years (range 26-76). We treated 67 aneurysms with a mean of 1.4 1-3 PED per patient. We have no mortality and three post-procedural complications with clinical consequences, two of them severe with intracranial haemorrhage and the other with anterior choroidal artery thrombosis. Follow-up was in 45 patients (65 aneurysm) achieving complete occlusion in 90.8% at 12 months of follow-up. Two aneurysms which remained without any changes were distal and fusiform including main bifurcations (3.1%).

CONCLUSION

Treatment by PED of fusiform or wide-neck saccular aneurysms is associated with high rates of occlusion after six and 12 months. Correct selection of the patients, aneurysms and also specific characteristics of the Pipeline device should be known in order to select the best therapeutic option. Our findings suggest that the indication must be judged case by case in the selection of suitable patients for PED therapy.

摘要

未标注

血流导向装置是治疗梭形动脉瘤和宽颈囊状动脉瘤的一种有用工具,在这项技术出现之前,这些动脉瘤的治疗存在问题。Pipeline™栓塞装置(PED)在多个系列研究中被描述,显示出高闭塞率且相对安全。

目的

展示2010年2月至2013年10月期间巴塞罗那四个不同神经介入中心使用PED(柯惠公司)的经验。

方法

我们回顾性分析了2010年2月至2013年10月期间在巴塞罗那四个神经介入中心接受PED治疗的患者。

结果

治疗了42例(89.4%)未破裂动脉瘤患者和5例(10.6%)蛛网膜下腔出血后患者,平均年龄51岁(范围26 - 76岁)。我们治疗了67个动脉瘤,每位患者平均使用1.4个1 - 3枚PED。无死亡病例,有3例术后并发症伴有临床后果,其中2例严重,发生颅内出血,另1例为脉络膜前动脉血栓形成。45例患者(65个动脉瘤)进行了随访,随访12个月时完全闭塞率为90.8%。2个无任何变化的动脉瘤位于远端且为梭形,包括主要分支(3.1%)。

结论

PED治疗梭形或宽颈囊状动脉瘤在6个月和12个月后具有较高的闭塞率。为了选择最佳治疗方案,应了解患者、动脉瘤的正确选择以及Pipeline装置的具体特性。我们的研究结果表明在选择适合PED治疗的患者时,必须逐例判断适应证。

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