State Key Lab of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, China.
J Am Chem Soc. 2016 May 11;138(18):5773-6. doi: 10.1021/jacs.6b02401. Epub 2016 May 3.
Although significant progress has been achieved with short peptide nanostructures, the construction of switchable membrane assemblies remains a great challenge. Here we report short α-peptide assemblies that undergo thermo-reversible switching between assembly and disassembly states, triggered by the conformational change of laterally grafted short peptides from a folded α-helix to a random coil conformation. The α-helical peptide based on two oligoether dendron side groups forms flat disks, while the peptide helix based on three dendron side groups forms hollow vesicles. The vesicular membrane can spontaneously capture a racemic mixture through the self-formation of vesicular containers upon heating and enantioselectively release the chiral guest molecule through preferential diffusion across the vesicular walls.
尽管短肽纳米结构已经取得了重大进展，但构建可切换的膜组件仍然是一个巨大的挑战。在这里，我们报告了短α-肽组装体，它们可以通过从折叠的α-螺旋到无规卷曲构象的侧接短肽的构象变化，在组装和解组装状态之间进行热可逆切换。基于两个聚醚树枝状侧基的α-螺旋肽形成扁平盘，而基于三个树枝状侧基的肽螺旋形成中空囊泡。囊泡膜可以通过加热时囊泡容器的自形成自发地捕获外消旋混合物，并通过优先穿过囊泡壁扩散来对映选择性地释放手性客体分子。
