Kemeny D M, Lessof M H, Patel S, Youlten L J, Williams A, Lambourn E
United Medical School Department of Allergy and Allied Respiration Disorders London, UK.
Int Arch Allergy Appl Immunol. 1989;88(1-2):247-9. doi: 10.1159/000234799.
IgG and IgE antibody levels have been followed for a period of 2 years in patients receiving immunotherapy with bee and wasp venom. 106 adult patients who had had anaphylactic reactions to wasp stings had initially low IgG antibody levels to wasp venom which rose with therapy (p less than 0.001). IgE antibody levels also showed an initial rise but subsequently fell (p less than 0.001). The pattern was similar to that previously reported in children who had had anaphylactic reactions to bee stings, but who, after a course of immunotherapy, were able to tolerate stings with impunity. 60 adults who had had anaphylactic reactions to bee stings showed a different pattern, with initially high IgG antibody levels which did not rise further. Since two thirds of this group were beekeepers or members of beekeeper's families, the high initial IgG antibody levels could have been a response to the frequent stings to which such individuals are prone. The fact that high levels did not protect against anaphylaxis shows, however, that the classical concept of 'blocking antibody' is in need of revision.
对接受蜜蜂和黄蜂毒液免疫疗法的患者，随访观察了2年的IgG和IgE抗体水平。106例对黄蜂蜇刺有过敏反应的成年患者，最初对黄蜂毒液的IgG抗体水平较低，随着治疗而升高（p<0.001）。IgE抗体水平起初也升高，但随后下降（p<0.001）。这种模式与先前报道的对蜜蜂蜇刺有过敏反应的儿童相似，这些儿童在接受一个疗程的免疫疗法后能够耐受蜇刺而无不良后果。60例对蜜蜂蜇刺有过敏反应的成年患者表现出不同的模式，最初IgG抗体水平较高，且未进一步升高。由于该组三分之二的患者是养蜂人或养蜂人的家庭成员，最初较高的IgG抗体水平可能是对这类个体容易遭受的频繁蜇刺的一种反应。然而，高水平抗体不能预防过敏反应这一事实表明，经典的“封闭抗体”概念需要修正。
