Arrang J M, Garbarg M, Lancelot J C, Lecomte J M, Pollard H, Robba M, Schunack W, Schwartz J C
Unité 109 de Neurobiologie et Pharmacologie, Centre Paul-Broca, INSERM, Paris, France.
Int Arch Allergy Appl Immunol. 1989;88(1-2):79-81. doi: 10.1159/000234753.
The third histamine receptor was first identified on brain neurons and seems also to be present in other cells such as the lung mast cells. Hence the novel and potent H3 receptor agonist (R)-alpha-methylhistamine might find therapeutic applications in allergic diseases.
第三种组胺受体最初是在脑神经元上被识别出来的,而且似乎也存在于其他细胞中,比如肺肥大细胞。因此,新型强效H3受体激动剂(R)-α-甲基组胺可能在过敏性疾病中找到治疗应用。