Debruyne D, Commeau P, Grollier G, Huret B, Scanu P, Moulin M
Laboratory of Pharmacology, University Hospital Centre of Caen, France.
Int J Clin Pharmacol Res. 1989;9(1):15-9.
Twenty patients in a stable condition suffering from congestive heart failure were treated with digoxin for at least three weeks and then with nicardipine concomitantly for five days. No statistically significant variation in serum digoxin concentrations determined at seven control times during a 24-hour period or in its mean concentration was found in the two groups of values examined before and after the concurrent nicardipine treatment. The mean increase of 6.8% in the AUC0----24h was not significant either. Since the maximum increase in serum digoxin concentrations at the steady state never exceeded 0.5 ng/ml, a toxic effect is not likely to occur in patients whose digoxin levels are normally monitored.
20例病情稳定的充血性心力衰竭患者接受地高辛治疗至少3周，然后同时加用尼卡地平治疗5天。在尼卡地平联合治疗前后检查的两组数值中，未发现24小时内7个对照时间点测定的血清地高辛浓度或其平均浓度有统计学意义的变化。AUC0-24h平均增加6.8%也无显著意义。由于稳态时血清地高辛浓度的最大增加值从未超过0.5 ng/ml，因此在常规监测地高辛水平的患者中不太可能发生毒性作用。
