70%异丙醇中的2%葡萄糖酸氯己定在预防中心静脉导管相关感染方面是否比常规使用的葡萄糖酸氯己定溶液更有效：一项多中心随机试验的初步研究（国际标准随机对照试验编号：ISRCTN2657745）？
Is 2% chlorhexidine gluconate in 70% isopropyl alcohol more effective at preventing central venous catheter-related infections than routinely used chlorhexidine gluconate solutions: A pilot multicenter randomized trial (ISRCTN2657745)?
作者信息
McCann Margaret, Fitzpatrick Fidelma, Mellotte George, Clarke Michael
机构信息
School of Nursing and Midwifery, Trinity College Dublin, Dublin, Ireland.
Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Microbiology, Beaumont Hospital, Dublin, Ireland.
出版信息
Am J Infect Control. 2016 Aug 1;44(8):948-9. doi: 10.1016/j.ajic.2016.02.019. Epub 2016 Apr 11.
A pilot randomized trial in 3 Irish outpatient hemodialysis units compared 2% chlorhexidine gluconate (CHG) in 70% isopropyl alcohol with routinely used CHG solutions for central venous catheter exit site antisepsis. We found no significant difference between the groups for the prevention of catheter-related bloodstream infections (1/53 vs 2/52; relative risk [RR], 0.49; 95% confidence interval [CI], 0.05-5.25; P = .55) and catheter-associated bloodstream infections (1/53 vs 4/52; RR, 0.25; 95% CI, 0.03-2.12; P = .16).
在爱尔兰的3个门诊血液透析单元进行的一项试点随机试验，将70%异丙醇中的2%葡萄糖酸氯己定（CHG）与常规使用的CHG溶液用于中心静脉导管出口部位的消毒进行了比较。我们发现，两组在预防导管相关血流感染（1/53 vs 2/52；相对风险[RR]，0.49；95%置信区间[CI]，0.05 - 5.25；P = 0.55）和导管相关血流感染（1/53 vs 4/52；RR，0.25；95% CI，0.03 - 2.12；P = 0.16）方面没有显著差异。
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