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英国肾脏协会血液透析血管通路临床实践指南。

UK Kidney Association Clinical Practice Guideline on vascular access for haemodialysis.

作者信息

Aitken Emma, Anijeet Hameed, Ashby Damien, Barrow Wayne, Calder Francis, Dowds Brett, Fielding Catherine, Gilbert James, Jones Rob, Karunanithy Narayan, Khawaja Zaib, Roberts Emma, Robson Mike, Shroff Rukshana, Stacey Hannah, Thomson Peter, Waters Dan

机构信息

Queen Elizabeth University Hospital, Glasgow, UK.

Royal Liverpool University Hospital, Liverpool, UK.

出版信息

BMC Nephrol. 2025 Aug 14;26(1):461. doi: 10.1186/s12882-025-04374-y.

Abstract

This guideline is written primarily for doctors and nurses working in dialysis centres and related areas of medicine in the UK, and is an update of a previous version written in 2015. It aims to provide guidance on how to provide vascular access care for patients approaching and undergoing haemodialysis, and provides a standard of care which centres should in general aim to achieve. We would not advise patients to interpret the guideline as a rulebook, but perhaps to answer the question: "What does good quality vascular access care look like?". The guideline is split into sections: each begins with a few statements which are graded by strength (1 is a firm recommendation, 2 is more like a sensible suggestion), and the type of research available to back up the statement, ranging from A (good quality trials so we are pretty sure this is right) to D (more like the opinion of experts than known for sure). After the statements there is a short summary explaining why we think this, often including a discussion of some of the most helpful research. There is then a list of the most important medical articles so that you can read further if you want to - most of this is freely available online, at least in summary form. A few notes on the individual sections: 1.  This section covers key concepts relevant to vascular access and focusses on access type selection, including a historical introduction and review of the key literature informing our understanding. This explains why we are moving away from the outdated advice in previous guidelines (e.g. that 'all patients should dialyse with a fistula as first choice') towards a process which treats dialysis access selection as a choice, respecting patient individuality, aiming to provide high quality assessment and advice, so that patients are supported in making informed decisions. The basic concept of the fistula as optimal access is highlighted and remains valid, but it is placed within a more modern concept of care, in which the patient is at the centre of the decision process. 2.  This section addresses the initial planning of access, from education and vein preservation, through to the timing of assessment and access formation, emphasising in particular the need to plan ahead. 3.  This section deals with the formation and routine care of AV access (fistulas and grafts), covering access type and configuration, surgical and anaesthetic technique, the maturation period (before a fistula is ready to be used), and initiation and maintenance of optimal cannulation (needling). 4.  This section deals with some of the complications of AV access. Research in this area is ongoing and not yet sufficient to give clear guidance, so we emphasise again the importance of involving patients in treatment decisions. 5.  This section deals with the placement and routine care of catheter access (lines), covering location, technique, anticoagulant locks, and regular exit site disinfection and dressings. 6.  This section deals with catheter complications, like infection and poor flow, which are sometimes life-threatening, and for which the catheter sometimes needs to be changed. 7.  This section deals with central venous stenosis (narrowing of veins deep in the chest) which is mostly a long term complication of catheters, but which is relevant to the planning of all types of access. We thought this important condition deserved its own section. Most of the concepts relevant to adult patients apply equally to children and adolescents, so there is no separate Paediatric section, and unless stated, guidance applies to children as well as adults. Where they do exist, differences are highlighted within the statements and rationale, sometimes with separate paragraphs or subheadings. Access for peritoneal dialysis is not included in this guideline since it is covered elsewhere, and the guideline is not exhaustive, with several aspects not covered, though they may be addressed in future versions. The guideline's principle focus is areas of mainstream practice for which there is variation across different UK centres, in general not covering newly developed or rarely practiced techniques, and it is not intended to replace handbooks and review articles. The guideline's main anticipated audience is NHS professionals caring for patients who are receiving or planning haemodialysis, but it is written to be as accessible as possible to patients and carers also. There are appendices at the end which explain the meaning of words and concepts which are used throughout the guideline, especially the medical and statistical terminology. CLINICAL TRIAL NUMBER: Not applicable.

摘要

本指南主要面向在英国透析中心及相关医学领域工作的医生和护士,是对2015年编写的上一版指南的更新。其目的是就如何为即将接受和正在接受血液透析的患者提供血管通路护理提供指导,并提供各中心总体应努力达到的护理标准。我们不建议患者将本指南视为一本规则手册,而或许它能回答这样一个问题:“高质量的血管通路护理是什么样的?”本指南分为多个部分:每个部分开头都有一些按强度分级的陈述(1为坚定推荐,2更像是合理建议),以及支持该陈述的可用研究类型,范围从A(高质量试验,所以我们相当确定这是正确的)到D(更像是专家意见而非确切已知的)。陈述之后是一个简短的总结,解释我们为何这样认为,通常包括对一些最有帮助的研究的讨论。然后是最重要的医学文章列表,以便如果您愿意可以进一步阅读——其中大部分至少以摘要形式可在网上免费获取。关于各部分的一些说明:1. 本节涵盖与血管通路相关的关键概念,重点是通路类型选择,包括历史介绍以及对形成我们理解的关键文献的回顾。这解释了我们为何要摒弃先前指南中过时的建议(例如“所有患者应以动静脉内瘘作为首选进行透析”),转而采用将透析通路选择视为一种选择的过程,尊重患者个体差异,旨在提供高质量评估和建议,以便支持患者做出明智决策。动静脉内瘘作为最佳通路的基本概念得到强调且仍然有效,但它被置于更现代的护理概念中,在这个概念里患者处于决策过程的中心。2. 本节涉及通路的初始规划,从教育和静脉保护,到评估和通路形成的时机,特别强调提前规划的必要性。3. 本节论述动静脉通路(内瘘和移植物)的形成及常规护理,涵盖通路类型和配置、手术及麻醉技术、成熟阶段(内瘘准备好使用之前)以及最佳穿刺(针刺)的启动和维持。4. 本节论述动静脉通路的一些并发症。该领域的研究仍在进行中,尚未足以给出明确指导,所以我们再次强调让患者参与治疗决策的重要性。5. 本节论述导管通路(管路)的放置及常规护理,涵盖位置、技术、抗凝锁以及定期出口部位消毒和换药。6. 本节论述导管并发症,如感染和血流量不佳,这些有时会危及生命,为此有时需要更换导管。7. 本节论述中心静脉狭窄(胸部深处静脉变窄),这主要是导管的一种长期并发症,但与所有类型通路的规划都相关。我们认为这个重要情况值得单独设节。与成年患者相关的大多数概念同样适用于儿童和青少年,所以没有单独的儿科部分,除非另有说明,指南适用于儿童和成人。存在差异的地方在陈述和理由中会突出显示,有时会有单独段落或小标题。本指南未包括腹膜透析通路,因为它在其他地方有涉及,并且本指南并不详尽,有几个方面未涵盖,不过它们可能会在未来版本中提及。本指南的主要重点是英国不同中心存在差异的主流实践领域,一般不涵盖新开发或很少实践的技术,并且它无意取代手册和综述文章。本指南主要预期受众是为接受或计划接受血液透析的患者提供护理的英国国家医疗服务体系(NHS)专业人员,但编写时也尽可能便于患者和护理人员理解。末尾有附录解释贯穿指南使用的单词和概念的含义,特别是医学和统计术语。临床试验编号:不适用。

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