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2型糖尿病药物治疗综述

Type 2 Diabetes Medication Review.

作者信息

Sterrett James J, Bragg Scott, Weart Charles Wayne

机构信息

South Carolina College of Pharmacy, Charleston, South Carolina.

South Carolina College of Pharmacy, Charleston, South Carolina.

出版信息

Am J Med Sci. 2016 Apr;351(4):342-55. doi: 10.1016/j.amjms.2016.01.019. Epub 2016 Feb 2.

Abstract

BACKGROUND

Patients with type 2 diabetes and their healthcare providers have a variety of medication options available for treating elevated blood glucose values. These medication choices have expanded drastically over the last 10 years with a large number of glucose lowering medications gaining FDA approval.

METHODS

Here, we have included an extensive search of the type 2 diabetes literature focusing on articles which impact patient-oriented evidence that maters (POEMs).

RESULTS

Choosing the best agent(s) can be challenging and requires weighing the risks and benefits of each particular medication. Tailoring medications to individual patients should be prioritized based on trials with cardiovascular outcome data, potential hemoglobin A1c reduction/goal, serious medication precautions and side-effects, co-morbid medical conditions, and cost.

CONCLUSIONS

This paper will provide the reader with an overview of the pros and cons for each antiglycemic medication class and specific drugs where appropriate. Data relevant to most patient centered encounters will be provided, including safety, tolerability, efficacy, cost, and simplicity of use.

摘要

背景

2型糖尿病患者及其医疗服务提供者有多种药物可用于治疗血糖升高。在过去10年中,这些药物选择大幅增加,大量降糖药物获得了美国食品药品监督管理局(FDA)的批准。

方法

在此,我们对2型糖尿病文献进行了广泛检索,重点关注影响以患者为导向的重要证据(POEMs)的文章。

结果

选择最佳药物可能具有挑战性,需要权衡每种特定药物的风险和益处。应根据心血管结局数据试验、潜在的糖化血红蛋白降低/目标、严重的用药注意事项和副作用、合并的内科疾病以及成本,优先为个体患者量身定制药物。

结论

本文将向读者概述每种降糖药物类别的优缺点以及适当时的特定药物。将提供与大多数以患者为中心的诊疗相关的数据,包括安全性、耐受性、疗效、成本和使用的简便性。

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