口服壬二酸酯可降低超重男性人体的胰岛素抵抗标志物。
Oral Azelaic Acid Ester Decreases Markers of Insulin Resistance in Overweight Human Male Subjects.
机构信息
New Frontier Labs L.L.C., San Antonio, TX, U.S.A.
Louden Consulting, Bandera, TX, U.S.A.
出版信息
In Vivo. 2020 May-Jun;34(3):1173-1186. doi: 10.21873/invivo.11890.
Abstract
BACKGROUND/AIM: Insulin resistance (IR) is linked to increased risk of cardiovascular disease and cancer. We examined safety and efficacy of the natural product diethyl azelate (DEA) in overweight males with a varying degree of IR.
PATIENTS AND METHODS
Seventeen subjects [age 18-42, hemoglobin A1c (A1c) of 5.2-6.2%] received orally 1 mg/kg DEA daily for 21 days. Blood plasma glucose, insulin and lipid levels were assessed before and after treatment.
RESULTS
DEA was well tolerated without hypoglycemia or adverse effects except transient diarrhea (n=1). DEA significantly reduced fasting glucose by 6.06 mg/dl (n=8) and insulin by 37.8% (n=8) in subjects with IR and/or A1c ≥5.6%. Furthermore, it improved cholesterol/HDL, LDL/HDL, and non-cholesterol HDL/HDL by 5.4, 6.5, and 6.6%, respectively in all subjects, and by 8.0, 9.8, and 9.8%, respectively in 9 subjects with A1c ≥5.6%.
CONCLUSION
DEA efficacy correlates with the degree of IR. DEA holds promise as a novel treatment for the management of IR.
摘要
背景/目的：胰岛素抵抗（IR）与心血管疾病和癌症风险增加有关。我们研究了天然产物二乙基己酸（DEA）在具有不同程度 IR 的超重男性中的安全性和疗效。
患者和方法
17 名受试者[年龄 18-42 岁，糖化血红蛋白（A1c）为 5.2-6.2%]每天口服 1mg/kg 的 DEA，共 21 天。治疗前后评估血浆血糖、胰岛素和血脂水平。
结果
DEA 耐受性良好，无低血糖或不良反应，仅 1 例出现短暂性腹泻（n=1）。在有 IR 和/或 A1c≥5.6%的受试者中，DEA 使空腹血糖降低了 6.06mg/dl（n=8），胰岛素降低了 37.8%（n=8）。此外，它使所有受试者的胆固醇/HDL、LDL/HDL 和非胆固醇 HDL/HDL 分别提高了 5.4%、6.5%和 6.6%，在 A1c≥5.6%的 9 名受试者中，分别提高了 8.0%、9.8%和 9.8%。
结论
DEA 的疗效与 IR 的程度相关。DEA 有望成为治疗 IR 的新方法。
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