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高敏肌钙蛋白T和N末端脑钠肽前体在预测先天性膈疝预后中的作用：一项多中心随机对照试验的结果

High-Sensitivity Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Prediction of Outcome in Congenital Diaphragmatic Hernia: Results from a Multicenter, Randomized Controlled Trial.

作者信息

Snoek Kitty G, Kraemer Ulrike S, Ten Kate Chantal A, Greenough Anne, van Heijst Arno, Capolupo Irma, Schaible Thomas, van Rosmalen Joost, Wijnen René M, Reiss Irwin K M, Tibboel Dick

机构信息

Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.

Division of Asthma, Allergy and Lung Biology, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, Denmark Hill, London, United Kingdom.

出版信息

J Pediatr. 2016 Jun;173:245-249.e4. doi: 10.1016/j.jpeds.2016.03.026. Epub 2016 Apr 11.

DOI:10.1016/j.jpeds.2016.03.026
PMID:27079964
Abstract

UNLABELLED

Biomarkers may be helpful in prediction of outcomes of infants with congenital diaphragmatic hernia. The predictive value of high-sensitivity troponin T and N-terminal pro-brain natriuretic peptide was investigated in 128 infants with congenital diaphragmatic hernia. After correction for multiple testing, those biomarkers did not predict severe pulmonary hypertension, death, need of extracorporeal membrane oxygenation, or bronchopulmonary dysplasia.

TRIAL REGISTRATION

Netherlands Trial Registry: 1310.

摘要

未标注

生物标志物可能有助于预测先天性膈疝婴儿的预后。对128例先天性膈疝婴儿研究了高敏肌钙蛋白T和N末端脑钠肽前体的预测价值。在进行多重检验校正后，这些生物标志物不能预测严重肺动脉高压、死亡、体外膜肺氧合需求或支气管肺发育不良。

试验注册

荷兰试验注册中心：1310。

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