通过协同钯/铜催化，还原交叉偶联共轭芳基烯烃和芳基溴化物与硅烷。
Reductive Cross-Coupling of Conjugated Arylalkenes and Aryl Bromides with Hydrosilanes by Cooperative Palladium/Copper Catalysis.
机构信息
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.
Fukui Institute for Fundamental Chemistry, Kyoto University, Sakyo-ku, Kyoto, 606-8103, Japan.
出版信息
Angew Chem Int Ed Engl. 2016 May 17;55(21):6275-9. doi: 10.1002/anie.201511975. Epub 2016 Apr 15.
A method for the reductive cross-coupling of conjugated arylalkenes and aryl bromides with hydrosilanes by cooperative palladium/copper catalysis was developed, thus resulting in the highly regioselective formation of various 1,1-diarylalkanes, including a biologically active molecule. Under the applied reaction conditions, high levels of functional-group tolerance were observed, and the reductive cross-coupling of internal alkynes with aryl bromides afforded trisubstituted alkenes.
发展了一种通过协同钯/铜催化还原交叉偶联共轭芳基烯烃和芳基溴化物与硅烷的方法，从而高区域选择性地形成各种 1,1-二芳基烷烃，包括一种生物活性分子。在应用的反应条件下，观察到高官能团容忍度，并且芳基溴化物与内部炔烃的还原交叉偶联得到三取代烯烃。
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