Oral Ebru, Doshi Brinda N, Gul Rizwan M, Neils Andrew L, Kayandan Sanem, Muratoglu Orhun K
Harris Orthopedic Laboratory, Massachusetts General Hospital, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.
J Biomed Mater Res B Appl Biomater. 2017 Aug;105(6):1379-1389. doi: 10.1002/jbm.b.33662. Epub 2016 Apr 15.
Radiation crosslinked ultrahigh molecular weight polyethylene (UHMWPE) is the bearing surface material most commonly used in total joint arthroplasty because of its excellent wear resistance. Crosslinking agents such as peroxides can also effectively increase wear resistance but peroxide crosslinked UHMWPE has low oxidative stability. We hypothesized that the addition of an antioxidant to peroxide crosslinked UHMWPE could improve its oxidation resistance and result in mechanical, tribological, and oxidative properties equivalent to currently utilized radiation crosslinked UHMWPEs. Various vitamin E (0.1-1.0 wt % and peroxide concentration (0.5-1.5 wt %) combinations were studied to investigate changes in crosslink density, wear rate, mechanical properties, and oxidative stability in comparison to radiation crosslinked UHMWPE. Peroxide crosslinking was more efficient as compared to radiation crosslinking in the presence of vitamin E with the former resulting in lower wear rate with vitamin E concentrations above 0.3 wt %. The tensile mechanical properties were comparable to and the impact strength was higher than those of the clinically relevant radiation crosslinked controls. We also determined that gamma sterilization of peroxide crosslinked vitamin E blends improved wear resistance further. In summary, peroxide crosslinking of vitamin E-blended UHMWPE may provide a feasible and economical alternative to radiation for achieving clinically relevant properties for total joint implants using UHMWPE. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1379-1389, 2017.
辐射交联超高分子量聚乙烯（UHMWPE）因其优异的耐磨性，是全关节置换术中最常用的承重表面材料。过氧化物等交联剂也能有效提高耐磨性，但过氧化物交联的UHMWPE氧化稳定性较低。我们假设，在过氧化物交联的UHMWPE中添加抗氧化剂可以提高其抗氧化性，并使其机械性能、摩擦学性能和氧化性能与目前使用的辐射交联UHMWPE相当。研究了各种维生素E（0.1 - 1.0 wt%）和过氧化物浓度（0.5 - 1.5 wt%）的组合，以研究与辐射交联UHMWPE相比，交联密度、磨损率、机械性能和氧化稳定性的变化。在维生素E存在的情况下，过氧化物交联比辐射交联更有效，当维生素E浓度高于0.3 wt%时，前者的磨损率更低。拉伸机械性能与临床相关的辐射交联对照相当，冲击强度更高。我们还确定，过氧化物交联的维生素E共混物经伽马灭菌后耐磨性进一步提高。总之，维生素E共混的UHMWPE的过氧化物交联可能为使用UHMWPE的全关节植入物实现临床相关性能提供一种可行且经济的辐射替代方法。© 2016威利期刊公司。《生物医学材料研究杂志》B部分：应用生物材料，105B：1379 - 1389，2017年。
