利用微核试验研究低剂量放射性碘治疗甲亢患者的细胞遗传毒性。
Study of cytogenetic toxicity of low-dose radioiodine therapy in hyperthyroid patients using a micronuclei assay.
作者信息
Parida Girish K, Bal Chandrasekhar, Dada Rima, Tripathi Madhavi, Dwivedi Sadanand
机构信息
Departments of aNuclear Medicine bAnatomy cBiostatistics, All India Institute of Medical Sciences, New Delhi, India.
出版信息
Nucl Med Commun. 2016 Aug;37(8):800-4. doi: 10.1097/MNM.0000000000000519.
OBJECTIVE
Radioiodine, in low doses, has been used as a treatment modality for hyperthyroidism worldwide for a long time. However, there is little information available on the severity of cytotoxicity of radioiodine at these low doses. The present investigation aimed to study the cytogenetic toxicity of low-dose radioiodine in hyperthyroid patients using a cytokinesis-blocked micronuclei (MN) assay.
MATERIALS AND METHODOLOGY
All of the patients received radioiodine in the form of sodium iodine (oral form). Blood samples of these patients were collected before therapy and 3 months after therapy, and lymphocytes were analysed for MN assay.
RESULTS
Peripheral blood lymphocytes were analysed in 74 hyperthyroid patients (52 men, 22 women). The results indicated a positive relationship between age and the frequency of MN. However, there was no statistically significant difference in MN frequency at 3 months after therapy in comparison with that before therapy.
CONCLUSION
This study showed that the cytogenetic damage produced by low-dose radioiodine was transient and reversible. Thus, patients can be motivated to undergo this safe and easy procedure as a modality of treatment for hyperthyroidism.
目的
长期以来，低剂量放射性碘在全球范围内一直被用作治疗甲状腺功能亢进症的一种方式。然而，关于这些低剂量放射性碘的细胞毒性严重程度的信息却很少。本研究旨在通过胞质分裂阻滞微核（MN）试验研究低剂量放射性碘对甲状腺功能亢进症患者的细胞遗传毒性。
材料与方法
所有患者均接受碘化钠形式（口服）的放射性碘治疗。在治疗前和治疗后3个月采集这些患者的血样，并对淋巴细胞进行微核试验分析。
结果
对74例甲状腺功能亢进症患者（52例男性，22例女性）的外周血淋巴细胞进行了分析。结果表明年龄与微核频率之间存在正相关关系。然而，治疗后3个月的微核频率与治疗前相比，差异无统计学意义。
结论
本研究表明，低剂量放射性碘产生的细胞遗传损伤是短暂且可逆的。因此，可以鼓励患者接受这种安全简便的治疗方法来治疗甲状腺功能亢进症。
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