Goisbault Manon, Simon Laure, Hanf Mathieu, Darmaun Dominique, Rozé Jean-Christophe, Flamant Cyril
Department of Neonatal Medicine, Hx00F4;pital Mx00E8;re et Enfant, CHU de Nantes, Nantes, France.
Neonatology. 2016;110(2):125-8. doi: 10.1159/000444473. Epub 2016 Apr 18.
Birth length is correlated to height at 2 years and is a predictor of adult height. However, little is known about the relationship between length growth during neonatal hospitalization and height at 2 years.
The objective was to determine the relationship between length growth during neonatal hospitalization and height at 2 years in preterm infants.
A total of 1,760 preterm infants of less than 35 weeks of gestational age were included. Neonatal length growth was defined by the difference between length Z-scores at discharge and at birth according to Olsen curves. We calculated the odds ratios (OR) before and after adjustment for the risk of being in the 1st quintile of the height Z-score at 2 years.
Height at 2 years was positively associated with birth length (p < 0.001) and with neonatal length growth (p < 0.001), whereas birth length and neonatal length growth were inversely correlated (p < 0.001). The risk of being in the 1st quintile of the height Z-score at 2 years was significantly associated with birth length (adjusted OR = 0.43, 95% CI: 0.38-0.49, for one Z-score) and with neonatal length growth (adjusted OR = 0.66, 95% CI: 0.56-0.76, for one Z-score) before and after adjustment for perinatal variables.
In addition to birth length, neonatal length growth was associated with height at 2 years. These findings point to the need for a close follow-up of the length of preterm infants during hospitalization, so as to start an early management of those patients.
出生时身长与2岁时的身高相关，且是成人身高的一个预测指标。然而，关于新生儿住院期间身长增长与2岁时身高之间的关系，人们知之甚少。
本研究旨在确定早产儿在新生儿住院期间的身长增长与2岁时身高之间的关系。
共纳入1760例孕周小于35周的早产儿。根据奥尔森曲线，新生儿身长增长定义为出院时与出生时身长Z评分的差值。我们计算了在调整2岁时身高Z评分处于第一五分位数风险前后的优势比（OR）。
2岁时的身高与出生时身长呈正相关（p<0.001），与新生儿身长增长也呈正相关（p<0.001），而出生时身长与新生儿身长增长呈负相关（p<0.001）。在调整围产期变量前后，2岁时身高Z评分处于第一五分位数的风险与出生时身长显著相关（调整后的OR=0.43，95%CI：0.38-0.49，每增加一个Z评分），与新生儿身长增长也显著相关（调整后的OR=0.66，95%CI：0.56-0.76，每增加一个Z评分）。
除出生时身长外，新生儿身长增长也与2岁时的身高相关。这些发现表明，需要在住院期间密切随访早产儿身长，以便对这些患儿尽早进行管理。
