Macromolecular Chemistry Research Group, Dept. of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Spain.
Macromolecular Chemistry Research Group, Dept. of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Spain; Basque Center for Materials, Applications and Nanostructures (BCMaterials), Parque Tecnológico de Bizkaia, Ed. 500, Derio 48160, Spain.
Carbohydr Polym. 2016 Jun 25;144:25-32. doi: 10.1016/j.carbpol.2016.02.043. Epub 2016 Feb 18.
In this work we develop poly(L-lactide)/branched β-cyclodextrin (bβCD) blends in an attempt to obtain new biocompatible and biodegradable materials to be used in the emerging fields of pharmaceutical, biomedicine and food industry. Ionic branched β-cyclodextrin (bβCD) was obtained by polycondensation of the β-CD monomer and it was blended with a commercially available PLLA. Fourier transform infrared spectroscopy (FTIR) has been applied to study the occurring interactions between both partners. Thermal properties of blends have been analyzed by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA), while the phase structure of the blends was analyzed by scanning electron microscopy (SEM). Finally, dynamic mechanical analysis (DMA) has been used to provide further insights into the features controlling miscibility between PLLA and bβCD. Results show the presence of a single phase irrespectively of the blend composition. Overall, this work opens new perspectives for the development of naturally available materials with tunable functional properties for applications in which cyclodextrins emerge as a new class of promising candidates.
在这项工作中，我们开发了聚（L-丙交酯）/支化β-环糊精（bβCD）共混物，试图获得新的生物相容性和可生物降解材料，用于新兴的制药、生物医学和食品工业领域。离子支化β-环糊精（bβCD）通过β-CD 单体的缩聚获得，并与市售的 PLLA 共混。傅里叶变换红外光谱（FTIR）已用于研究两种物质之间发生的相互作用。通过差示扫描量热法（DSC）和热重分析（TGA）分析了共混物的热性能，而通过扫描电子显微镜（SEM）分析了共混物的相结构。最后，动态力学分析（DMA）用于进一步了解控制 PLLA 和 bβCD 之间混溶性的特征。结果表明，无论共混物组成如何，均存在单相。总的来说，这项工作为开发具有可调节功能特性的天然可用材料开辟了新的前景，这些材料可用于环糊精作为一类有前途的新型候选材料的新兴应用。
