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脂质体阿糖胞苷治疗儿童和青少年中枢神经系统肿瘤软脑膜播散

[Liposomal cytarabine for the treatment of leptomeningeal dissemination of central nervous system tumours in children and adolescents].

作者信息

Moreno Lucas, García Ariza Miguel Angel, Cruz Ofelia, Calvo Carlota, Fuster Jose Luis, Salinas Jose Antonio, Moscardo Cristina, Portugal Raquel, Merino Jose Manuel, Madero Luis

机构信息

Servicio de Onco-Hematología Pediátrica, Hospital Infantil Universitario Niño Jesús, Madrid, España; Instituto de Investigación La Princesa, Madrid, España.

Servicio de Oncología Pediátrica, Hospital de Cruces, Bilbao, Vizcaya, España.

出版信息

An Pediatr (Barc). 2016 Nov;85(5):274.e1-274.e8. doi: 10.1016/j.anpedi.2016.02.007. Epub 2016 Apr 13.

DOI:10.1016/j.anpedi.2016.02.007
PMID:27086069
Abstract

Leptomeningeal dissemination in paediatric central nervous system (CNS) tumours is associated with a poor outcome, and new therapeutic strategies are desperately needed. One of the main difficulties in the treatment of CNS tumours is blood brain barrier penetration. Intrathecal therapy has shown to be effective in several paediatric tumours. The aim of this article is to review the data available on the use of liposomal cytarabine for paediatric patients with leptomeningeal dissemination of CNS tumours, including the pharmacology, administration route, safety and efficacy data.

摘要

小儿中枢神经系统（CNS）肿瘤的软脑膜播散与预后不良相关，因此迫切需要新的治疗策略。治疗CNS肿瘤的主要困难之一是血脑屏障的穿透。鞘内治疗已被证明在几种小儿肿瘤中有效。本文的目的是综述有关脂质体阿糖胞苷用于小儿CNS肿瘤软脑膜播散患者的现有数据，包括药理学、给药途径、安全性和疗效数据。

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[Liposomal cytarabine for the treatment of leptomeningeal dissemination of central nervous system tumours in children and adolescents].脂质体阿糖胞苷治疗儿童和青少年中枢神经系统肿瘤软脑膜播散
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