来自大叶鼠尾草根部的保肝二萜类化合物。
Hepatoprotective diterpenoids from the roots of Salvia grandifolia.
作者信息
Kang Jie, Zhang Ting, Li Li, Sun Hua, Wang Ding-Ding, Chen Ruo-Yun
机构信息
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
b Institute of Medical Information & Library, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
出版信息
J Asian Nat Prod Res. 2016 May;18(5):504-8. doi: 10.1080/10286020.2015.1130705. Epub 2016 Apr 18.
One new diterpenoid, grandifolia G (1), together with a known diterpenoid (6,7,8,8a-tetrahydro-6,6-dimethyl-2-oxonaphtho[1,8-bc]furan-3-yl)-4-methylfuran-3-carboxylic acid (2), was isolated from 70% EtOH extract of root of Salvia grandifolia. Their structures were determined by UV, IR, HRESIMS, NMR spectra. Compounds 1 and 2 (10 μM) exhibited hepatoprotective activities (61 and 55%) against DL-galactosamine-induced cell damage in HL-7702 cells.
从荔枝草根的70%乙醇提取物中分离得到一个新的二萜类化合物大叶鼠尾草素G（1），以及一个已知的二萜类化合物（6,7,8,8a-四氢-6,6-二甲基-2-氧代萘并[1,8-bc]呋喃-3-基）-4-甲基呋喃-3-羧酸（2）。通过紫外光谱、红外光谱、高分辨电喷雾电离质谱和核磁共振光谱确定了它们的结构。化合物1和2（10 μM）对DL-半乳糖胺诱导的HL-7702细胞损伤具有保肝活性（分别为61%和55%）。
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