一种由三氯化铁催化的高度区域选择性1,2-加成/取代序列，用于构建香豆素取代的双(吲哚基)甲烷。
A FeCl3-catalyzed highly regioselective 1,2-addition/substitution sequence for the construction of coumarin-substituted bis(indolyl)methanes.
作者信息
Wang Wen-Bo, Zhu Yan-Shuo, Guo Sheng-Qiang, Wang Qi-Lin, Bu Zhan-Wei
机构信息
College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China.
出版信息
Org Biomol Chem. 2016 May 11;14(19):4420-5. doi: 10.1039/c6ob00515b.
PMID:27086776
Abstract
A FeCl3-catalyzed highly regioselective 1,2-addition/substitution sequence of 3-acetylcoumarins and indoles has been developed to afford highly hindered tetrasubstituted bis(indolyl)methanes bearing a biologically useful coumarin motif in 56-99% yields.
摘要
已开发出一种由三氯化铁催化的3-乙酰基香豆素与吲哚的高度区域选择性1,2-加成/取代反应序列，以56%至99%的产率得到带有具有生物学用途的香豆素基序的高度受阻的四取代双(吲哚基)甲烷。
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