脾切除术与急性胰腺炎风险增加相关：台湾地区的一项病例对照研究
Splenectomy Correlates With Increased Risk of Acute Pancreatitis: A Case-Control Study in Taiwan.
作者信息
Lai Shih-Wei, Lin Cheng-Li, Liao Kuan-Fu
机构信息
College of Medicine, China Medical University.
出版信息
J Epidemiol. 2016 Sep 5;26(9):488-92. doi: 10.2188/jea.JE20150214. Epub 2016 Apr 16.
OBJECTIVE
The objective of the study was to investigate the association between splenectomy and acute pancreatitis.
METHODS
We conducted a case-control study using the database of the Taiwan National Health Insurance Program. We included 7666 subjects aged 20-84 years with first-time acute pancreatitis during the period of 1998-2011 as cases and 30 664 randomly selected subjects without acute pancreatitis as controls. Both cases and controls were matched for sex, age, and index year of acute pancreatitis diagnosis. The association of acute pancreatitis with splenectomy was examined using a multivariable unconditional logistic regression model and reported as an odds ratio and its 95% confidence interval (CI).
RESULTS
After adjustment for covariables, the adjusted odds ratio of acute pancreatitis was 2.90 for subjects with splenectomy (95% CI, 1.39-6.05) compared with subjects without splenectomy.
CONCLUSIONS
Splenectomy is associated with acute pancreatitis. Further studies are necessary to clarify the underlying mechanism.
目的
本研究的目的是调查脾切除术与急性胰腺炎之间的关联。
方法
我们使用台湾国民健康保险计划的数据库进行了一项病例对照研究。我们纳入了1998年至2011年期间首次发生急性胰腺炎的7666名年龄在20 - 84岁之间的受试者作为病例组，并随机选择30664名无急性胰腺炎的受试者作为对照组。病例组和对照组在性别、年龄以及急性胰腺炎诊断的索引年份方面进行了匹配。使用多变量无条件逻辑回归模型检查急性胰腺炎与脾切除术之间的关联，并报告为比值比及其95%置信区间（CI）。
结果
在对协变量进行调整后，与未进行脾切除术的受试者相比，进行脾切除术的受试者发生急性胰腺炎的调整后比值比为2.90（95%CI，1.39 - 6.05）。
结论
脾切除术与急性胰腺炎有关。有必要进行进一步研究以阐明潜在机制。
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