基于人群的研究：心血管疾病与急性胰腺炎风险。

Cardiovascular disease and risk of acute pancreatitis in a population-based study.

机构信息

Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

出版信息

Pancreas. 2013 Aug;42(6):1011-5. doi: 10.1097/MPA.0b013e318287cb62.

DOI:10.1097/MPA.0b013e318287cb62

PMID:23851434

Abstract

OBJECTIVES

The low-grade inflammation that characterizes cardiovascular disorders may facilitate the development of pancreatitis; therefore, we investigated the connection between cardiovascular disorders and acute pancreatitis.

METHODS

A nested population-based case-control study was conducted in Sweden in 2006-2008. Cases had a first episode of acute pancreatitis diagnosed in the nationwide Patient Register. Controls were matched on age, sex, and calendar year and randomly selected from all Swedish residents (40-84 years old). Exposure to cardiovascular diseases (hypertension, ischemic heart disease, congestive heart failure, and stroke) was identified in the Patient Register. Relative risk of acute pancreatitis was estimated by odds ratios with 95% confidence intervals using logistic regression adjusting for confounders (matching variables, alcohol disease, chronic obstructive pulmonary disease, type 2 diabetes, number of distinct medications, and other cardiovascular diseases).

RESULTS

The study included 6161 cases and 61,637 control subjects. Cardiovascular disorders were positively associated with acute pancreatitis (adjusted odds ratio, 1.35; 95% confidence interval, 1.25-1.45).

CONCLUSIONS

This population-based study indicates an association between cardiovascular disease and acute pancreatitis. Specifically, ischemic heart disease and hypertension seem to increase the risk of acute pancreatitis. Further research is needed to determine causality.

摘要

目的

心血管疾病的低度炎症可能促进胰腺炎的发展；因此，我们研究了心血管疾病与急性胰腺炎之间的关系。

方法

在 2006-2008 年，在瑞典进行了一项基于人群的嵌套病例对照研究。病例组为全国患者登记处诊断的首次急性胰腺炎发作。对照组按年龄、性别和日历年份与病例组匹配，并从所有瑞典居民（40-84 岁）中随机选择。心血管疾病（高血压、缺血性心脏病、充血性心力衰竭和中风）的暴露情况在患者登记处确定。使用 logistic 回归调整混杂因素（匹配变量、酒精性疾病、慢性阻塞性肺疾病、2 型糖尿病、不同药物的数量和其他心血管疾病）后，通过比值比及其 95%置信区间估计急性胰腺炎的相对风险。