Krasner N
Gastrointestinal Unit, Walton Hospital, Liverpool, UK.
Int J Colorectal Dis. 1989;4(1):2-5. doi: 10.1007/BF01648540.
Since 1983 the Neodymium-YAG laser has been used endoscopically to treat 93 patients with inoperable colorectal carcinoma and 18 patients with benign sessile adenomas. In an additional 11 patients with colorectal cancer, photodynamic therapy (PDT) has been applied using an argon-pumped dye laser. Objective and subjective measurements of quality of life have shown the beneficial effects of the Nd-YAG laser in the relief of symptoms, and four patients have apparently been rendered disease free. Benign tumours also respond to Nd-YAG ablation but close histological supervision is necessary to detect malignant transformation at an early stage. Although PDT may offer a potential for cure in small inoperable tumours, it seems likely that Nd-YAG laser treatment will remain the laser option of choice for advanced bulky tumours.
自1983年以来，钕钇铝石榴石激光已被用于内镜治疗93例无法手术的结直肠癌患者和18例良性无蒂腺瘤患者。另外11例结直肠癌患者采用了氩泵浦染料激光进行光动力疗法（PDT）。对生活质量的客观和主观测量显示，钕钇铝石榴石激光在缓解症状方面具有有益效果，且有4例患者明显实现了无病状态。良性肿瘤对钕钇铝石榴石激光消融也有反应，但需要密切的组织学监测以早期发现恶性转化。虽然光动力疗法可能为无法手术的小肿瘤提供治愈潜力，但钕钇铝石榴石激光治疗似乎仍将是晚期巨大肿瘤的首选激光治疗方法。
