寨卡病毒 NS1 结构揭示黄病毒属中静电表面的多样性。
Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses.
机构信息
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.
出版信息
Nat Struct Mol Biol. 2016 May;23(5):456-8. doi: 10.1038/nsmb.3213. Epub 2016 Apr 18.
The association of Zika virus (ZIKV) infections with microcephaly has resulted in an ongoing public-health emergency. Here we report the crystal structure of a C-terminal fragment of ZIKV nonstructural protein 1 (NS1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis and immune evasion. Comparison with West Nile and dengue virus NS1 structures reveals conserved features but diverse electrostatic characteristics at host-interaction interfaces, thus possibly implying different modes of flavivirus pathogenesis.
寨卡病毒（ZIKV）感染与小头症的关联已导致持续的公共卫生紧急情况。在这里，我们报告了 ZIKV 非结构蛋白 1（NS1）的 C 端片段的晶体结构，该蛋白是一种主要的宿主相互作用分子，在黄病毒复制、发病机制和免疫逃逸中发挥作用。与西尼罗河病毒和登革热病毒 NS1 结构的比较显示出保守特征，但在宿主相互作用界面上具有不同的静电特征，因此可能暗示了不同的黄病毒发病机制模式。
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