Goldstein Sue W, Gonzalez Joshua R, Gagnon Catherine, Goldstein Irwin
San Diego Sexual Medicine, San Diego, CA, USA.
San Diego Sexual Medicine, San Diego, CA, USA.
Sex Med. 2016 Sep;4(3):e166-75. doi: 10.1016/j.esxm.2016.03.026. Epub 2016 Apr 15.
Female sexual arousal disorder is a pathophysiologic state characterized clinically by persistent or recurrent inability to attain or maintain an adequate lubrication-swelling response of sexual excitement until completion of sexual activity. Prior clinical experience with alprostadil products for men with erectile dysfunction supports its use in women with female sexual arousal disorder.
To compare the effect of topical alprostadil with over-the-counter (OTC) lubricant on female genital arousal in the absence of visual sexual stimuli.
Healthy premenopausal women without sexual dysfunction were recruited from the community to participate in the study. Of 17 women who consented, 10 were enrolled and completed the trial. The mean age of subjects was 32 years (range = 27-43). Study drug or placebo was applied topically to the genitals. Continuous temperature monitoring was performed. Participants completed questionnaires assessing genital sensation, effect, intensity, and duration.
Change in temperature from baseline in vestibule, clitoris and vulva.
In all 10 subjects, topical alprostadil induced a statistically significant increase in temperature of the vestibule, clitoris, and vulva compared with the OTC lubricant. The most rapid difference in genital temperature between placebo and alprostadil was seen on the vulva, which demonstrated a significant difference at approximately 9 minutes. There was a significant difference in temperature seen for the vestibule and clitoris at 11 and 19 minutes, respectively. Sixty percent of women reported being aware or conscious of genital sensations with topical alprostadil, but not with OTC lubricant. Discordance was noted in 30% of subjects who reported being aware or conscious of genital sensations with the two treatments and 10% who reported not being aware or conscious of genital sensations with either treatment.
Topical alprostadil administered to healthy premenopausal women induced statistically significant, sustained increases in genital temperatures of the vestibule, clitoris, and vulva within 20 minutes compared with OTC lubricant.
女性性唤起障碍是一种病理生理状态，临床上表现为在性活动结束前持续或反复无法达到或维持足够的性兴奋润滑-肿胀反应。既往使用前列地尔产品治疗男性勃起功能障碍的临床经验支持其用于治疗女性性唤起障碍。
比较在无视觉性刺激的情况下，局部应用前列地尔与非处方（OTC）润滑剂对女性生殖器唤起的影响。
从社区招募无性功能障碍的健康绝经前女性参与本研究。17名同意参与的女性中，10名被纳入并完成试验。受试者的平均年龄为32岁（范围=27-43岁）。将研究药物或安慰剂局部应用于生殖器。进行连续体温监测。参与者完成评估生殖器感觉、效果、强度和持续时间的问卷。
前庭、阴蒂和外阴温度相对于基线的变化。
与OTC润滑剂相比，在所有10名受试者中，局部应用前列地尔使前庭、阴蒂和外阴的温度有统计学意义的显著升高。安慰剂和前列地尔之间生殖器温度的最快差异出现在外阴，在大约9分钟时显示出显著差异。前庭和阴蒂的温度分别在11分钟和19分钟时出现显著差异。60%的女性报告使用局部前列地尔时能感知或意识到生殖器感觉，而使用OTC润滑剂时则不能。30%的受试者报告在两种治疗中能感知或意识到生殖器感觉，10%的受试者报告在两种治疗中均不能感知或意识到生殖器感觉，存在不一致情况。
与OTC润滑剂相比，对健康绝经前女性局部应用前列地尔在20分钟内使前庭、阴蒂和外阴的生殖器温度有统计学意义的显著持续升高。
