产超广谱β-内酰胺酶和碳青霉烯酶的肠杆菌科细菌中携带mcr-1质粒的完整序列
Complete Sequences of mcr-1-Harboring Plasmids from Extended-Spectrum-β-Lactamase- and Carbapenemase-Producing Enterobacteriaceae.
作者信息
Li Aiqing, Yang Yong, Miao Minhui, Chavda Kalyan D, Mediavilla José R, Xie Xiaofang, Feng Ping, Tang Yi-Wei, Kreiswirth Barry N, Chen Liang, Du Hong
机构信息
Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
出版信息
Antimicrob Agents Chemother. 2016 Jun 20;60(7):4351-4. doi: 10.1128/AAC.00550-16. Print 2016 Jul.
Abstract
Here we completely sequenced four mcr-1-haboring plasmids, isolated from two extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1-harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST25 isolates were identical (all pMCR1-IncX4), belonging to the IncX4 incompatibility group, while the plasmid from an E. coli ST2085 isolate (pMCR1-IncI2) belongs to the IncI2 group. A nearly identical 2.6-kb mcr-1-pap2 element was found to be shared by all mcr-1-carrying plasmids.
摘要
在此，我们对从两株产超广谱β-内酰胺酶（ESBL）的大肠埃希菌和两株产碳青霉烯酶的肺炎克雷伯菌临床分离株中分离得到的4个携带mcr-1的质粒进行了全序列测定。来自一株大肠埃希菌序列型2448（ST2448）分离株和两株肺炎克雷伯菌ST25分离株的携带mcr-1的质粒是相同的（均为pMCR1-IncX4），属于IncX4不相容群，而来自一株大肠埃希菌ST2085分离株的质粒（pMCR1-IncI2）属于IncI2群。发现所有携带mcr-1的质粒都共享一个几乎相同的2.6 kb mcr-1-pap2元件。
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