Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, PR China, PR China.
Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, PR China, PR China.
Photodiagnosis Photodyn Ther. 2016 Jun;14:191-9. doi: 10.1016/j.pdpdt.2016.04.005. Epub 2016 Apr 16.
Acne, a disease of pilosebaceous unit, is a common dermatologic disorder affecting about 80%-95% of people in both genders in adulthood. The available treatment options are conventional topical and/or oral medications, which are associated with adverse effects, partial response only, contraindications and reoccurrences. This necessitates the need for the introduction of novel treatment for improving acne lesions.
The aim of writing this review is to provide evidence-based information regarding safety and efficacy of PDT in treating acne lesions.
The search term 'Acne and PDT' were entered into a search of the National Library of Medicine's PubMed Database. The search returned a total of 143 sources among which 36 studies pertaining to the use of PDT in acne are included in this review article.
36 clinical trials were selected among which 24 trials were performed to see the effect of PDT in acne whereas 12 trials compared the effect of PDT with light or laser alone therapy. Among 24 trials that used PDT only, 3 were clinical trials with control, 14 were clinical trials without control, 6 were randomized controlled trials (RCT) and 1 was retrospective study. On the basis of results of these trials, it is seen that PDT is safe and effective method of treatment for acne lesions. Studies have shown that PDT can control both inflammatory and non-inflammatory acne lesions and can improve all severity of lesions from mild to severe.
Photodynamic therapy (PDT) has been extensively studied and found to be effective treatment modality for acne lesions. However, more RCTs are needed to establish standard guidelines regarding concentrations and incubation period of photosensitizers and optimal parameters of light sources. Further studies are needed to guide future research and help dermatologist to choose PDT as an effective treatment modality for treating acne lesions.
痤疮是一种发生于毛囊皮脂腺的慢性炎症性疾病，是一种常见的皮肤科疾病，在成年男女中的发病率约为 80%-95%。现有的治疗方法包括传统的局部和/或口服药物，但这些方法都存在不良反应、疗效有限、存在禁忌症和易复发等问题。因此，有必要引入新的治疗方法来改善痤疮皮损。
本文旨在提供 PDT 治疗痤疮皮损的安全性和有效性的循证医学信息。
在国家医学图书馆的 PubMed 数据库中输入检索词“痤疮和 PDT”进行检索。检索共返回了 143 个来源，其中有 36 项研究涉及 PDT 在痤疮中的应用，这些研究被纳入本综述。
共选择了 36 项临床试验，其中 24 项研究评估了 PDT 在痤疮中的疗效，12 项研究比较了 PDT 与单独使用光或激光治疗的效果。在仅使用 PDT 的 24 项试验中，有 3 项为有对照的临床试验，14 项为无对照的临床试验，6 项为随机对照试验（RCT），1 项为回顾性研究。基于这些试验的结果，我们可以看到 PDT 是一种安全有效的治疗痤疮皮损的方法。研究表明， PDT 可以控制炎症性和非炎症性痤疮皮损，并可以改善从轻度到重度的所有严重程度的皮损。
光动力疗法（PDT）已被广泛研究，被认为是治疗痤疮皮损的有效方法。然而，需要更多的 RCT 来建立关于光敏剂的浓度和孵育时间以及光源最佳参数的标准指南。需要进一步的研究来指导未来的研究，并帮助皮肤科医生选择 PDT 作为治疗痤疮皮损的有效治疗方法。
