Cooper J S, Steinfeld A D, Lerch I A
Division of Radiation Oncology, NYU Medical Center, NY 10016.
J Clin Oncol. 1989 May;7(5):619-21. doi: 10.1200/JCO.1989.7.5.619.
The response to radiotherapy of epidemic Kaposi's sarcoma (EKS) is unusual in that irradiated regions are frequently left with a persistent purple stain, reminiscent of the color of the original tumor, but with no tumor mass. To date there are no published data to indicate whether the persistence of pigmentation can be predicted beforehand or if it has any prognostic import. We reviewed the response to treatment of 118 EKS lesions that were irradiated at New York University (NYU) Medical Center between 1981 and 1986. A total of 86 responded to treatment by complete clearance of the mass. Of these, 29 left residual purple pigmentation within the treatment portal, while 57 did not. Complete response (CR; without residual pigmentation) occurred more often in patients who had higher Karnofsky scores at the time of treatment. However, in terms of ultimate local control or survival, there were no differences between patients whose lesions cleared completely v those in whom pigmentation remained. We conclude that persistent pigmentation represents only a benign remnant of irradiated EKS and has no prognostic import.
流行性卡波西肉瘤（EKS）对放疗的反应较为特殊，即接受放疗的区域常常会留下持久的紫色印记，这让人联想到原发肿瘤的颜色，但此处并无肿瘤肿块。迄今为止，尚无公开数据表明色素沉着的持续存在能否预先预测，或者它是否具有任何预后意义。我们回顾了1981年至1986年间在纽约大学（NYU）医学中心接受放疗的118例EKS病变的治疗反应。共有86例病变通过肿块完全清除对治疗产生反应。其中，29例在治疗野内留下了残留的紫色色素沉着，而57例没有。完全缓解（CR；无残留色素沉着）在治疗时卡氏评分较高的患者中更为常见。然而，就最终的局部控制或生存率而言，病变完全清除的患者与色素沉着残留的患者之间并无差异。我们得出结论，持续的色素沉着仅代表接受放疗的EKS的良性残余，并无预后意义。
