衰老过程中的聚（ADP - 核糖）聚合酶——是友还是敌？

Poly(ADP-Ribose) Polymerases in Aging - Friend or Foe?

作者信息

Vida András, Abdul-Rahman Omar, Mikó Edit, Brunyánszki Attila, Bai Peter

机构信息

Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, H- 4032 Debrecen, Egyetem tér 1, Hungary.

出版信息

Curr Protein Pept Sci. 2016;17(7):705-712. doi: 10.2174/1389203717666160419144959.

DOI:10.2174/1389203717666160419144959

PMID:27090903

Abstract

Poly(ADP-ribose) polymerases were originally described as DNA repair enzymes. PARP-1, PARP-2 and PARP-3 can be activated by DNA damage and the resulting activation of these enzymes that facilitate DNA repair, seems to be a prerequisite of successful aging. PARP activation helps to maintain genomic integrity through supporting DNA repair systems; however, in parallel these enzymes limit metabolic fitness and make the organism more prone for metabolic diseases. In addition, several other pathways (e.g., proteostasis, nutrient sensing, stem cell proliferation or cellular communication) all contributing to aging, were shown to be PARP mediated. In this review we aim to summarize our current knowledge on the role of PARPs in aging.

摘要

聚（ADP - 核糖）聚合酶最初被描述为DNA修复酶。PARP - 1、PARP - 2和PARP - 3可被DNA损伤激活，而这些酶的激活促进DNA修复，这似乎是成功衰老的一个先决条件。PARP激活通过支持DNA修复系统有助于维持基因组完整性；然而，与此同时，这些酶会限制代谢适应性，使生物体更容易患代谢性疾病。此外，其他几个有助于衰老的途径（如蛋白质稳态、营养感知、干细胞增殖或细胞通讯）已被证明是由PARP介导的。在这篇综述中，我们旨在总结目前关于PARP在衰老中的作用的知识。