Tung Jenny, Archie Elizabeth A, Altmann Jeanne, Alberts Susan C
Department of Evolutionary Anthropology, Box 90383, Duke University, Durham, North Carolina 27708, USA.
Duke Population Research Institute, Box 90989, Duke University, Durham, North Carolina 27708, USA.
Nat Commun. 2016 Apr 19;7:11181. doi: 10.1038/ncomms11181.
In humans and other animals, harsh circumstances in early life predict morbidity and mortality in adulthood. Multiple adverse conditions are thought to be especially toxic, but this hypothesis has rarely been tested in a prospective, longitudinal framework, especially in long-lived mammals. Here we use prospective data on 196 wild female baboons to show that cumulative early adversity predicts natural adult lifespan. Females who experience ≥3 sources of early adversity die a median of 10 years earlier than females who experience ≤1 adverse circumstances (median lifespan is 18.5 years). Females who experience the most adversity are also socially isolated in adulthood, suggesting that social processes partially explain the link between early adversity and adult survival. Our results provide powerful evidence for the developmental origins of health and disease and indicate that close ties between early adversity and survival arise even in the absence of health habit and health care-related explanations.
在人类和其他动物中，早年的恶劣环境预示着成年后的发病率和死亡率。多种不利条件被认为具有特别大的毒性，但这一假设很少在前瞻性纵向框架中得到验证，尤其是在长寿哺乳动物中。在此，我们利用196只野生雌性狒狒的前瞻性数据表明，早年累积的逆境预示着成年后的自然寿命。经历≥3种早年逆境来源的雌性比经历≤1种不利情况的雌性死亡时间中位数早10年（中位寿命为18.5年）。经历最多逆境的雌性在成年后也会被社会孤立，这表明社会因素部分解释了早年逆境与成年生存之间的联系。我们的结果为健康与疾病的发育起源提供了有力证据，并表明即使没有健康习惯和医疗保健相关的解释，早年逆境与生存之间也存在紧密联系。
