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在肯尼亚尼扬扎地区,治疗伙伴可提高接受抗逆转录病毒治疗的女性的门诊出勤率,但对男性没有效果。

Treatment Buddies Improve Clinic Attendance among Women but Not Men on Antiretroviral Therapy in the Nyanza Region of Kenya.

作者信息

Kibaara Charles, Blat Cinthia, Lewis-Kulzer Jayne, Shade Starley, Mbullo Patrick, Cohen Craig R, Bukusi Elizabeth A

机构信息

Family AIDS Care & Education Services (FACES), P.O. Box 614-40100, Kisumu, Kenya; Research Care and Training Program, Center for Microbiology Research, Kenya Medical Research Institute, Kisumu, Kenya.

Family AIDS Care & Education Services (FACES), P.O. Box 614-40100, Kisumu, Kenya; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, USA.

出版信息

AIDS Res Treat. 2016;2016:9124541. doi: 10.1155/2016/9124541. Epub 2016 Mar 22.

Abstract

Background. Kenyan antiretroviral (ART) guidelines encourage treatment buddies (TBy) to maximize treatment adherence. This study examined the effect of TBys on clinic attendance in men and women on ART. Methods. This retrospective cohort study included all adult patients initiating ART from August 2007 to December 2011 at four health facilities in Kenya. Data were abstracted from electronic medical records and analyzed using Poisson regression. Results. Of 2,430 patients, 2,199 (91%) had a TBy. Relationship between TBy and clinic attendance differed in females and males (interaction p = 0.09). After demographic and clinic factor adjustment, females with a TBy were 28% more likely to adhere to all appointments than those without (adjusted aRR = 1.28; 95% CI 1.08-1.53), whereas males were no more likely to adhere (aRR = 1.01; 95% CI 0.76-1.32). Males reported partner/spouse (33%) or brother (11%) as the TBy while females reported sister (17%), partner/spouse (14%), or another family member (12%). Multivariable analysis found no association between clinic attendance and TBy relationship in either gender. Conclusion. Clinic attendance was higher among women with TBys but not men. Results support TBys to help women achieve ART success; alternate strategies to bolster TBy benefits are needed for men.

摘要

背景。肯尼亚抗逆转录病毒治疗(ART)指南鼓励治疗伙伴(TBy)最大程度地提高治疗依从性。本研究调查了治疗伙伴对接受抗逆转录病毒治疗的男性和女性就诊情况的影响。方法。这项回顾性队列研究纳入了2007年8月至2011年12月在肯尼亚四个医疗机构开始接受抗逆转录病毒治疗的所有成年患者。数据从电子病历中提取,并使用泊松回归进行分析。结果。在2430名患者中,2199名(91%)有治疗伙伴。治疗伙伴与就诊情况之间的关系在女性和男性中有所不同(交互作用p = 0.09)。在对人口统计学和临床因素进行调整后,有治疗伙伴的女性比没有治疗伙伴的女性遵守所有预约的可能性高28%(调整后的aRR = 1.28;95% CI 1.08 - 1.53),而男性遵守预约的可能性没有增加(aRR = 1.01;95% CI 0.76 - 1.32)。男性报告的治疗伙伴为伴侣/配偶(33%)或兄弟(11%),而女性报告的治疗伙伴为姐妹(17%)、伴侣/配偶(14%)或其他家庭成员(12%)。多变量分析发现,在任何性别中,就诊情况与治疗伙伴关系之间均无关联。结论。有治疗伙伴的女性就诊率较高,但男性并非如此。结果支持治疗伙伴有助于女性实现抗逆转录病毒治疗成功;需要为男性制定其他策略来增强治疗伙伴的益处。

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