Jiang Zhi-Yong, Yang Chun-Tao, Hou Shu-Qun, Tian Kai, Wang Wei, Hu Qiu-Fen, Huang Xiang-Zhong
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, P. R. China.
Planta Med. 2016 May;82(8):742-6. doi: 10.1055/s-0042-104349. Epub 2016 Apr 19.
Five new diterpenoids (1-5) were isolated from the roots of Aralia melanocarpa, together with four known compounds, 7β-hydroxy-ent-pimara-8(14),15-diene-19-oic acid (6), 18-norpimara-8(14),15-dien-4-ol (7), ent-16βH,17-isovalerate-kauran-19-oic acid (8), and ent-16α,17-dihydroxykauran-19-oic acid (9). Based on the MS, IR, and NMR spectral analysis, the structures of the five new diterpenoids (1-5) were elucidated. The cytotoxic activities of compounds 1-9 were assayed, and compounds 1 and 2 showed cytotoxicity in four cancer cell lines with IC50s from 4.2 to 8.2 µM.
从黑果土当归的根部分离出5个新的二萜类化合物（1-5），以及4个已知化合物，7β-羟基-对映-海松-8(14),15-二烯-19-酸（6）、18-降海松-8(14),15-二烯-4-醇（7）、对映-16βH,17-异戊酸-贝壳杉烷-19-酸（8）和对映-16α,17-二羟基贝壳杉烷-19-酸（9）。通过质谱、红外光谱和核磁共振光谱分析，阐明了5个新二萜类化合物（1-5）的结构。测定了化合物1-9的细胞毒性活性，化合物1和2在4种癌细胞系中显示出细胞毒性，IC50值为4.2至8.2 μM。
