Torkhovskaya T I, Belova O V, Zimina I V, Kryuchkova A V, Moskvina S N, Bystrova O V, Arion V Ya, Sergienko V I
Vestn Ross Akad Med Nauk. 2015(6):727-33. doi: 10.15690/vramn573.
The review presents data on mutual influence of nervous system and thymus, realized through the neuroendocrine-immune interactions. The pres- ence of adrenergic and peptidergic nerves in thymus creates conditions for implementation of the effect of neuropeptides secreted by them. These neuropeptides induce activation of thymus cells receptors and influence on the main processes in thymus, including T-lymphocyte maturation, cytokine and hormones production. In turn, thymuspeptides and/or cytokines, controlled by them, enter the brain and exert influence on neuro- nalfunction, which creates the basis for changes of behavior and homeostasis maintenance in response to infection. Ageing and some infectious, autoimmune, neurodegenerative and cancer diseases are accompanied by distortion of interactions between thymus and central nervous system. Mechanisms of signaling pathways, which determine these interactions, are not revealed yet, and their understanding will promote the development of effective therapeutic strategies.
本综述介绍了神经系统与胸腺之间通过神经内分泌-免疫相互作用实现的相互影响的数据。胸腺中肾上腺素能和肽能神经的存在为它们所分泌的神经肽发挥作用创造了条件。这些神经肽诱导胸腺细胞受体活化，并影响胸腺中的主要过程，包括T淋巴细胞成熟、细胞因子和激素产生。反过来，由它们控制的胸腺肽和/或细胞因子进入大脑并对神经功能产生影响，这为感染时行为改变和内稳态维持奠定了基础。衰老以及一些感染性、自身免疫性、神经退行性和癌症疾病都伴随着胸腺与中枢神经系统之间相互作用的紊乱。决定这些相互作用的信号通路机制尚未明确，对其的了解将促进有效治疗策略的发展。
