Interleukin-12 serum level has prognostic value in patients with ST-segment elevation myocardial infarction.
作者信息
Zykov Mikhail V, Barbarash Olga L, Kashtalap Vasiliy V, Kutikhin Anton G, Barbarash Leonid S
机构信息
Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, Kemerovo 650002, Russian Federation.
Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, Kemerovo 650002, Russian Federation; Kemerovo State Medical Academy, Voroshilova Street 22A, Kemerovo 650029, Russian Federation.
出版信息
Heart Lung. 2016 Jul-Aug;45(4):336-40. doi: 10.1016/j.hrtlng.2016.03.007. Epub 2016 Apr 16.
OBJECTIVES
The study aimed to evaluate whether serum inflammatory markers have prognostic value in patients with ST-segment elevation myocardial infarction (STEMI).
BACKGROUND
The role of cytokine-driven inflammation in the development of postdischarge complications after STEMI is obscured.
METHODS
We recruited 214 patients who were admitted within 24 h of STEMI onset to our Institute. IL-1α, -6, -8, -10, -12, TNF-α, and CRP serum levels were measured on the 10-14th day after STEMI onset.
RESULTS
Serum levels of IL-12, TNF-α, and CRP were significantly higher in patients with 3 affected coronary arteries compared to those with 1 affected coronary artery. However, only Killip class II-IV at admission and IL-12 serum level ≥90.0 pg/mL were defined as statistically significant predictors of adverse outcome after 1 year of follow-up.
CONCLUSION
IL-12 serum level may be suggested as a candidate prognostic marker if measured 10-14 days after STEMI onset.
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