Zykov Mikhail V, Barbarash Olga L, Kashtalap Vasiliy V, Kutikhin Anton G, Barbarash Leonid S
Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, Kemerovo 650002, Russian Federation.
Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, Kemerovo 650002, Russian Federation; Kemerovo State Medical Academy, Voroshilova Street 22A, Kemerovo 650029, Russian Federation.
Heart Lung. 2016 Jul-Aug;45(4):336-40. doi: 10.1016/j.hrtlng.2016.03.007. Epub 2016 Apr 16.
The study aimed to evaluate whether serum inflammatory markers have prognostic value in patients with ST-segment elevation myocardial infarction (STEMI).
The role of cytokine-driven inflammation in the development of postdischarge complications after STEMI is obscured.
We recruited 214 patients who were admitted within 24 h of STEMI onset to our Institute. IL-1α, -6, -8, -10, -12, TNF-α, and CRP serum levels were measured on the 10-14th day after STEMI onset.
Serum levels of IL-12, TNF-α, and CRP were significantly higher in patients with 3 affected coronary arteries compared to those with 1 affected coronary artery. However, only Killip class II-IV at admission and IL-12 serum level ≥90.0 pg/mL were defined as statistically significant predictors of adverse outcome after 1 year of follow-up.
IL-12 serum level may be suggested as a candidate prognostic marker if measured 10-14 days after STEMI onset.
