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Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell-induced squamous cell carcinoma.肿瘤抑制因子的特性可能导致毛囊干细胞诱导的鳞状细胞癌中表型的异质性。
Exp Dermatol. 2016 Sep;25(9):733-5. doi: 10.1111/exd.13037. Epub 2016 Jun 30.
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Exploiting Mouse Models to Study Ras-Induced Cutaneous Squamous Cell Carcinoma.利用小鼠模型研究Ras诱导的皮肤鳞状细胞癌。
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Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy).对暴露于8-甲氧基补骨脂素(8-MOP)和紫外线A辐射(PUVA疗法)后的HRA/Skh小鼠鳞状细胞癌中p53肿瘤抑制基因、H-ras原癌基因和增殖细胞核抗原(PCNA)的分析。
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Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin.Smad4条件性敲除小鼠皮肤中的毛囊缺陷与鳞状细胞癌形成
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Genetic changes during mouse skin tumorigenesis.小鼠皮肤肿瘤发生过程中的基因变化。
Environ Health Perspect. 1991 Jun;93:41-4. doi: 10.1289/ehp.919341.
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Skin tumors induced by sorafenib; paradoxic RAS-RAF pathway activation and oncogenic mutations of HRAS, TP53, and TGFBR1.索拉非尼诱导的皮肤肿瘤;矛盾的 RAS-RAF 通路激活和 HRAS、TP53 和 TGFBR1 的致癌突变。
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Stem cell quiescence acts as a tumour suppressor in squamous tumours.干细胞静止作为一种肿瘤抑制因子在鳞状肿瘤中起作用。
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Species as Model Systems for Infectious Diseases.物种作为传染病模型系统。
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Cutaneous Papillomaviruses and Non-melanoma Skin Cancer: Causal Agents or Innocent Bystanders?皮肤乳头瘤病毒与非黑色素瘤皮肤癌:是致病因素还是无辜旁观者?
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The interplay of UV and cutaneous papillomavirus infection in skin cancer development.紫外线与皮肤乳头瘤病毒感染在皮肤癌发生过程中的相互作用。
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Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2.不同部位人毛囊上皮祖细胞龛的增殖模式存在差异,它们对前列腺素 D2 的反应也存在差异。
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本文引用的文献

1
Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma.致癌剂诱导和遗传诱导的小鼠皮肤鳞状细胞癌的基因组景观。
Nat Med. 2015 Aug;21(8):946-54. doi: 10.1038/nm.3878. Epub 2015 Jul 13.
2
Mutational landscape of aggressive cutaneous squamous cell carcinoma.侵袭性皮肤鳞状细胞癌的突变图谱
Clin Cancer Res. 2014 Dec 15;20(24):6582-92. doi: 10.1158/1078-0432.CCR-14-1768. Epub 2014 Oct 10.
3
Stem cell quiescence acts as a tumour suppressor in squamous tumours.干细胞静止作为一种肿瘤抑制因子在鳞状肿瘤中起作用。
Nat Cell Biol. 2014 Jan;16(1):99-107. doi: 10.1038/ncb2889. Epub 2013 Dec 15.
4
Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells.肿瘤衍生的乳酸改变抗肿瘤免疫反应:对髓源性抑制细胞和 NK 细胞的影响。
J Immunol. 2013 Aug 1;191(3):1486-95. doi: 10.4049/jimmunol.1202702. Epub 2013 Jul 1.
5
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1.头颈部鳞状细胞癌外显子组测序揭示 NOTCH1 中的失活突变。
Science. 2011 Aug 26;333(6046):1154-7. doi: 10.1126/science.1206923. Epub 2011 Jul 28.
6
Defining the origins of Ras/p53-mediated squamous cell carcinoma.定义 Ras/p53 介导的鳞状细胞癌的起源。
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7425-30. doi: 10.1073/pnas.1012670108. Epub 2011 Apr 18.
7
Ras oncogene mutations in basal cell carcinomas and squamous cell carcinomas of human skin.人类皮肤基底细胞癌和鳞状细胞癌中的Ras癌基因突变。
J Invest Dermatol. 1990 Apr;94(4):423-5. doi: 10.1111/1523-1747.ep12874504.
8
Ras gene mutation and amplification in human nonmelanoma skin cancers.人类非黑色素瘤皮肤癌中的Ras基因突变与扩增
Mol Carcinog. 1991;4(3):196-202. doi: 10.1002/mc.2940040306.

Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell-induced squamous cell carcinoma.

作者信息

Flores Aimee, Grant William, White Andrew C, Scumpia Phillip, Takahashi Rie, Lowry William E

机构信息

Molecular Biology Institute, UCLA, Los Angeles, CA, USA.

Eli and Edythe Broad Center for Regenerative Medicine, UCLA, Los Angeles, CA, USA.

出版信息

Exp Dermatol. 2016 Sep;25(9):733-5. doi: 10.1111/exd.13037. Epub 2016 Jun 30.

DOI:10.1111/exd.13037
PMID:27095696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5002244/
Abstract
摘要