卷曲蛋白4（Frizzled-4）中KTXXXW基序远端的C末端对于正常的散乱蛋白招募以及诺林（Norrin）刺激的依赖于Lef/Tcf的转录激活至关重要。
Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation.
作者信息
Bertalovitz Alexander C, Pau Milly S, Gao Shujuan, Malbon Craig C, Wang Hsien-Yu
机构信息
Department of Physiology & Biophysics, Health Sciences Center, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.
Department of Pharmacology, Health Sciences Center, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8651, USA.
出版信息
J Mol Signal. 2016 Feb 5;11:1. doi: 10.5334/1750-2187-11-1.
The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin.
G蛋白偶联受体（GPCR）的羧基（C）末端决定着其重要功能。卷曲蛋白（FZD）的KTXXXW基序C末端与散乱蛋白（DVL）的募集有关。通过对FZD4及其相关配体Norrin的研究，我们发现，在卷曲蛋白-4 C末端尾巴中，KTXXXW基序远端至少三个残基对于DVL募集以及响应Norrin时强大的依赖Lef/Tcf的转录激活至关重要。
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