Vahlensieck W, Naber K, Wagenlehner F, Fabry W
Fachklinik Urologie, Kurpark-Klinik Bad Nauheim, Klinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Gießen.
Urologische Klinik und Poliklinik der Technischen Universität München.
Aktuelle Urol. 2016 May;47(3):243-5. doi: 10.1055/s-0042-103198. Epub 2016 Apr 20.
100 consecutive cases after radical prostatectomy with a bacterial count of 10(4) CFU/ml in midstream urine were followed during urological inpatient rehabilitation without antibiotic treatment. Before discharge, a follow-up examination with a urine dipstick and a second urine culture were performed.
No symptomatic urinary tract infections (UTI) occurred during the average follow-up period of 15.2 days. Patients with unremarkable urine dipstick findings at follow-up (no leukocyturia and no haematuria and no nitrituria) had no relevant bacteriuria (≥10(5) CFU/ml).54 of urine culture controls before discharge were negative, 31 showed insignificant bacterial growth (≤10(4) CFU/ml) and 15 had a bacterial count≥10(5) CFU/ml. 4 patients (27%) with > 10(5) CFU/ml were successfully treated with antibiotics for clear signs of infection (fever, chills, leukocytosis); the other 11 patients were just followed further.
Even though almost all patients after radical prostatectomy continue to suffer from some discomfort that might be due to UTI, patients with 10(4) CFU/ml in midstream urine samples should not receive antibiotic treatment unless they have clear systemic symptoms of an infection, e. g. fever, chills or leukocytosis. Unremarkable urine dipstick findings during the follow-up period (no leukocyturia and no erythrocyturia and no nitrituria) rule out a relevant bacteriuria (≥10(5) CFU/ml). Clear systemic signs of infection during follow-up only occurred in 4 patients, who were successfully treated with test-adapted antibiotics.
对100例前列腺癌根治术后患者进行了研究,这些患者中段尿细菌计数为10⁴CFU/ml,在泌尿外科住院康复期间未接受抗生素治疗。出院前,进行了尿试纸检查和第二次尿培养的随访检查。
在平均15.2天的随访期内,未发生有症状的尿路感染(UTI)。随访时尿试纸检查结果无异常(无白细胞尿、无血尿、无亚硝酸盐尿)的患者没有相关菌尿(≥10⁵CFU/ml)。出院前54例尿培养对照为阴性,31例显示细菌生长不显著(≤10⁴CFU/ml),15例细菌计数≥10⁵CFU/ml。4例细菌计数>10⁵CFU/ml且有明确感染迹象(发热、寒战、白细胞增多)的患者成功接受了抗生素治疗;其他11例患者仅继续进行随访。
尽管几乎所有前列腺癌根治术后患者仍会因尿路感染而感到一些不适,但中段尿样本细菌计数为10⁴CFU/ml的患者,除非有明确的全身感染症状,如发热、寒战或白细胞增多,否则不应接受抗生素治疗。随访期间尿试纸检查结果无异常(无白细胞尿、无红细胞尿、无亚硝酸盐尿)可排除相关菌尿(≥10⁵CFU/ml)。随访期间仅4例患者出现明确的全身感染迹象,这些患者通过针对性抗生素治疗成功治愈。