尼日利亚西南部高血压患者的他汀类药物处方情况：研究结果及对未来的启示

Statin prescribing among hypertensive patients in southwest Nigeria: findings and implications for the future.

作者信息

Akunne Onyinye Onyeka, Godman Brian, Adedapo Aduragbenro Deborah, Truter Ilse, Fadare Joseph

机构信息

Department of Pharmacology & Therapeutics, University of Ibadan, Nigeria.

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital Huddinge, SE-141 86, Stockholm, Sweden.

出版信息

J Comp Eff Res. 2016 May;5(3):281-8. doi: 10.2217/cer.15.65. Epub 2016 Apr 20.

DOI:10.2217/cer.15.65

PMID:27097045

Abstract

BACKGROUND

Statins reduce cardiovascular risk, especially in patients with hypertension due to their concomitant blood pressure reducing effects. Prescribing generic statins minimizes cost and improves access.

AIMS

Ascertain current prescribing of statins in Nigeria and potential savings from the increased use of generic statins.

METHODS

Prospective study involving hypertensive patients attending University College Hospital (Ibadan, Nigeria).

RESULTS

In total, 228 hypertensive patients received statins. Atorvastatin was the most prescribed statin, followed by simvastatin, rosuvastatin and finally fluvastatin. Prescribed doses were less than one defined daily dose in the majority, with high use of originators. Average monthly potential savings from increased prescribing of generic statins was US$2635 for atorvastatin and US$10,578 for rosuvastatin.

CONCLUSION

A shift toward increased prescribing generic statins is recommended to minimize costs.

摘要

背景

他汀类药物可降低心血管疾病风险，尤其是对高血压患者，因为它们具有协同降低血压的作用。开具通用型他汀类药物可将成本降至最低并改善药物可及性。

目的

确定尼日利亚目前他汀类药物的处方情况以及增加使用通用型他汀类药物可能节省的费用。

方法

对在尼日利亚伊巴丹大学学院医院就诊的高血压患者进行前瞻性研究。

结果

共有228名高血压患者接受了他汀类药物治疗。阿托伐他汀是处方量最多的他汀类药物，其次是辛伐他汀、瑞舒伐他汀，最后是氟伐他汀。大多数患者的处方剂量低于一个规定日剂量，原研药的使用比例较高。增加通用型阿托伐他汀的处方量，每月平均可节省2635美元；增加通用型瑞舒伐他汀的处方量，每月平均可节省10578美元。