Csályi Kitti, Fazekas Dávid, Kadlecsik Tamás, Türei Dénes, Gul Leila, Horváth Balázs, Módos Dezső, Demeter Amanda, Pápai Nóra, Lenti Katalin, Csermely Péter, Vellai Tibor, Korcsmáros Tamás, Varga Máté
1 Department of Genetics, Eötvös Loránd University , Budapest, Hungary .
2 Max Delbrück Center for Molecular Medicine , Berlin, Germany .
Zebrafish. 2016 Dec;13(6):541-544. doi: 10.1089/zeb.2016.1277. Epub 2016 Apr 20.
Understanding living systems requires an in-depth knowledge of the signaling networks that drive cellular homeostasis, regulate intercellular communication, and contribute to cell fates during development. Several resources exist to provide high-throughput data sets or manually curated interaction information from human or invertebrate model organisms. We previously developed SignaLink, a uniformly curated, multi-layered signaling resource containing information for human and for the model organisms nematode Caenorhabditis elegans and fruit fly Drosophila melanogaster. Until now, the use of the SignaLink database for zebrafish pathway analysis was limited. To overcome this limitation, we created SignaFish ( http://signafish.org ), a fish-specific signaling resource, built using the concept of SignaLink. SignaFish contains more than 200 curation-based signaling interactions, 132 further interactions listed in other resources, and it also lists potential miRNA-based regulatory connections for seven major signaling pathways. From the SignaFish website, users can reach other web resources, such as ZFIN. SignaFish provides signaling or signaling-related interactions that can be examined for each gene or downloaded for each signaling pathway. We believe that the SignaFish resource will serve as a novel navigating point for experimental design and evaluation for the zebrafish community and for researchers focusing on nonmodel fish species, such as cyclids.
理解生命系统需要深入了解驱动细胞内稳态、调节细胞间通讯并在发育过程中影响细胞命运的信号网络。现有多种资源可提供来自人类或无脊椎动物模式生物的高通量数据集或人工整理的相互作用信息。我们之前开发了SignaLink，这是一个经过统一整理的多层信号资源，包含人类以及线虫秀丽隐杆线虫和果蝇黑腹果蝇等模式生物的信息。到目前为止，SignaLink数据库在斑马鱼信号通路分析中的应用有限。为克服这一限制，我们创建了SignaFish（http://signafish.org），这是一个基于SignaLink概念构建的鱼类特异性信号资源。SignaFish包含200多个基于整理的信号相互作用、其他资源中列出的132个进一步相互作用，并且还列出了七个主要信号通路中基于潜在miRNA的调控连接。用户可以从SignaFish网站访问其他网络资源，如ZFIN。SignaFish提供了可针对每个基因进行检查或针对每个信号通路进行下载的信号或信号相关相互作用。我们相信，SignaFish资源将成为斑马鱼研究群体以及专注于非模式鱼类物种（如丽鱼科鱼类）的研究人员进行实验设计和评估的新导航点。
