Krawczak Elizabeth M, Minuzzi Luciano, Simpson William, Hidalgo Maria Paz, Frey Benicio N
a MiNDS Neuroscience Graduate Program , McMaster University , Hamilton , ON , Canada.
b Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton , ON , Canada.
Chronobiol Int. 2016;33(7):791-801. doi: 10.3109/07420528.2016.1167077. Epub 2016 Apr 20.
Women with a diagnosis of bipolar and major depressive disorders are at higher risk to develop postpartum depression. The primary objective of this longitudinal study was to determine whether daily activity rhythms and sleep parameters differ between women with and without a history of a mood disorder across the perinatal period. A secondary objective was to determine whether changes in these parameters were associated with postpartum mood. In total, 33 women were included in this study, 15 of which had a history of a mood disorder (high-risk group) and 18 who did not (low-risk group). Sleep and daily rhythms were assessed subjectively and objectively during the third trimester (≥26 weeks gestation) and again at 6-12 weeks postpartum. Mood was also assessed at both time points. Women in the high-risk group showed greater subjective daily rhythms and sleep disturbances across the perinatal period. Objective sleep efficiency was worse in the high-risk group in the postpartum period. Changes in both subjective daily rhythms and objective sleep efficiency were predictive of changes in depressive symptoms across the perinatal period. These findings encourage the development of preventative therapeutics to ensure circadian rhythm and sleep stability throughout the perinatal period.
被诊断患有双相情感障碍和重度抑郁症的女性患产后抑郁症的风险更高。这项纵向研究的主要目的是确定在围产期，有和没有情绪障碍病史的女性之间的日常活动节律和睡眠参数是否存在差异。次要目的是确定这些参数的变化是否与产后情绪有关。本研究共纳入33名女性，其中15名有情绪障碍病史（高危组），18名没有（低危组）。在孕晚期（妊娠≥26周）和产后6 - 12周对睡眠和日常节律进行主观和客观评估。在两个时间点也对情绪进行了评估。高危组女性在围产期表现出更大的主观日常节律和睡眠障碍。高危组产后的客观睡眠效率更差。主观日常节律和客观睡眠效率的变化都可预测围产期抑郁症状的变化。这些发现促使人们开发预防性治疗方法，以确保整个围产期的昼夜节律和睡眠稳定性。
