Ma Chao, Shen Ding-Rong, Zhang Qing, Ding Yi-Qun, Wang Yuan-Xiang, Peng Le, Meng Bao-Ying, Ti Yun-Xing
Cardiovascular Center, Shenzhen Children's Hospital of Chinese Medical University, Shenzhen, Guangdong 518026, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2016 Apr;18(4):340-4. doi: 10.7499/j.issn.1008-8830.2016.04.012.
To preliminarily investigate the relationship between serum apelin level and pulmonary artery pressure in children with congenital heart disease.
One hundred and twenty-six children with congenital heart disease undergoing surgical treatment were enrolled as subjects. The serum level of apelin was determined before surgery and at 7 days after surgery. The ratio of pulmonary artery systolic pressure to aortic systolic pressure (Pp/Ps) was calculated before extracorporeal circulation. According to the Pp/Ps value, patients were classified into non-pulmonary arterial hypertension (PAH) group, mild PAH group, moderate PAH group, and severe PAH group. Pulmonary artery mean pressure was estimated by echocardiography at 7 days after surgery.
The non-PAH group had the highest serum level of apelin before and after surgery, followed by the mild PAH group, moderate PAH group, and severe PAH group (P<0.05). All groups had significantly increased serum levels of apelin at 7 days after surgery (P<0.05). The serum level of apelin was negatively correlated with pulmonary artery pressure before surgery (r=-0.51, P<0.05) and at 7 days after surgery (r=-0.54, P<0.05).
The decrease in serum apelin level is associated with the development of pulmonary hypertension in children with congenital heart disease. The significance of serum apelin in predicting the development and degree of pulmonary hypertension in children with congenital heart disease deserves further studies.
初步探讨先天性心脏病患儿血清Apelin水平与肺动脉压力之间的关系。
选取126例接受外科治疗的先天性心脏病患儿作为研究对象。于术前及术后7天测定血清Apelin水平。体外循环前计算肺动脉收缩压与主动脉收缩压之比（Pp/Ps）。根据Pp/Ps值将患者分为非肺动脉高压（PAH）组、轻度PAH组、中度PAH组和重度PAH组。术后7天通过超声心动图评估肺动脉平均压。
非PAH组术前及术后血清Apelin水平最高，其次为轻度PAH组、中度PAH组和重度PAH组（P<0.05）。所有组术后7天血清Apelin水平均显著升高（P<0.05）。术前（r=-0.51，P<0.05）及术后7天（r=-0.54，P<0.05）血清Apelin水平与肺动脉压力呈负相关。
先天性心脏病患儿血清Apelin水平降低与肺动脉高压的发生有关。血清Apelin在预测先天性心脏病患儿肺动脉高压发生及程度方面的意义值得进一步研究。
